实体瘤脑膜转移鞘内药物治疗进展

Progress in intrathecal therapy for solid tumor meningeal metastasis

实体瘤脑膜转移是肿瘤晚期一种灾难性的合并症,预后很差,目前缺乏有效的治疗方法。鞘内化疗作为脑膜转移癌治疗的一种方法,虽然得到了许多指南或者专家共识的推荐,在临床实践中也经常应用,但鞘内化疗的疗效一直缺乏高质量研究证据的支持。甲氨蝶呤、阿糖胞苷、塞替派等鞘内化疗常用的药物疗效并不理想。本文对新型鞘内注射药物的用法、疗效和安全性进行总结。

Solid tumor meningeal metastasis is a catastrophic complication in the late stage of tumors,with a poor prognosis and currently lacking effective treatment methods.As a treatment method for meningeal metastasis,intrathecal chemotherapy has been recommended by many guidelines or expert consensus,and is often used in clinical practice.However,the efficacy of intrathecal chemotherapy has always lacked high-quality research evidence to support it.The efficacy of commonly used intrathecal chemotherapy drugs such as methotrexate,cytarabine,and thiotepa is not ideal.This article summarizes the usage,efficacy,and safety of new intrathecal injection drugs.