原发性肝癌多模式生物成像及特异性靶向探针

Multimodality imaging and specific targeting probes for primary liver cancer

原发性肝癌是发病率和死亡率最高的恶性肿瘤之一,严重威胁中国人民的生命安全和身体健康。因此,实现原发性肝癌的早期和精准诊断至关重要。临床上传统的影像学方法可以为肝癌提供形态学上的影像信息,但尚存在一定的局限性。多模式生物成像技术融合了各成像技术的优势,能获取更全面的诊断信息。结合肝癌特异性靶向探针,多模式生物成像技术较传统影像技术有更高的敏感度和特异度,不仅可以同时提供原发性肝癌的结构和功能信息,实现肝癌的精准诊断,还可在术中进行实时导航成像,指导原发性肝癌的术中决策。由此可见,多模式生物成像对原发性肝癌的临床诊疗具有重要意义。本文主要聚焦于原发性肝癌的多模式生物成像技术以及特异性靶向探针,综述了相关领域的研究现状。

Primary liver cancer(PLC)is one of the most common malignant diseases with the highest incidence and mortality rate,which poses a serious threat to public health in China.Thus,it is crucial to realize the early and accurate diagnosis of PLC.In clinical practice,traditional imaging techniques can provide the morphological information of liver cancer tissues,but they still have some limitations.Multimodality imaging can provide more comprehensive diagnostic information by integrating the advantages of different imaging technologies.By using liver cancer-specific targeting probes,multimodality imaging technology can achieve higher sensitivity and specificity than traditional imaging techniques.It can not only help with the accurate diagnosis of liver cancer by providing the structural and functional information of PLC simultaneously,but also guide surgeons to make better intraoperative decisions for PLC patients by supporting real-time navigation imaging during surgery.Therefore,multimodality imaging is of great significance to the clinical diagnosis and treatment of PLC.This review mainly focuses on the multimodality imaging technology and specific targeting probes of PLC,and summarizes the current research progress in this field.