跨膜蛋白TMEM176B及其相关疾病的研究进展

Advances in transmembrane protein TMEM176B and its related diseases

跨膜蛋白176B(transmembrane protein 176b,TMEM176B),最初称为TORID,是一种具有4个潜在跨膜结构域的主要表达于淋巴组织的跨膜蛋白。在树突状细胞的成熟、抗原交叉呈递以及肿瘤细胞的行为中发挥调节作用,并且影响移植物抗宿主病、神经系统疾病和肿瘤等疾病的发生和发展。本文就TMEM176B的结构、定位、生物学功能及其在疾病中的作用进行综述,以期为后续研究TMEM176B的功能及相关疾病的干预提供参考。

Transmembrane protein 176B(TMEM176B),originally known as TORID,is a transmembrane protein with four potential transmembrane structural domains that are predominantly expressed in lymphoid tissue.It plays a regulatory role in dendritic cell maturation,antigen cross-presentation,and tumor cell behavior,and influences the development of diseases such as graft-versus-host disease,neurological disorders and tumors.In this paper,the structure,localization and biological functions of TMEM176B and its role in diseases are reviewed,with the aim of providing a reference for subsequent studies on the function of TMEM176B and interventions in related diseases.