铁死亡在消化系统恶性肿瘤中的研究进展

Research progress of ferroptosis in digestive system cancers

铁死亡是一种独特的细胞死亡的新形式,其特征包括铁依赖性氧化损伤、脂质过氧化物和活性氧过量堆积。当前,有关铁死亡在各类消化系统恶性肿瘤中作用的研究进展迅速。多项研究发现,通过影响铁死亡信号通路中相关靶基因的表达可以抑制癌细胞的生长,因此调控铁死亡在肿瘤治疗中具有巨大的潜力。本文着重介绍了当前铁死亡在消化系统恶性肿瘤中的研究进展,并进一步总结了铁死亡相关分子及信号通路在消化系统恶性肿瘤中的作用机制及铁死亡相关药物在消化系统恶性肿瘤中的临床应用效果和研究进展,最后讨论了癌症中铁死亡的未来研究方向和目前尚未解决的问题,旨在从不同角度为铁死亡在消化系统恶性肿瘤中的重要作用提供理论依据,为消化系统恶性肿瘤提供新的铁死亡相关治疗方案,并希望为进一步进行转化研究提供一些方向。

Ferroptosis is a unique new form of cell death,which is characterized by iron-dependent oxidative damage,excessive accumulation of lipid peroxides and reactive oxygen species(ROS).Rapid progress has been made for understanding the roles of ferroptosis in various malignant tumors of the digestive system.As revealed by multiple research works,cancer cell growth could be inhibited through regulating the expression of target genes that are involved in the signaling pathways of ferroptosis,highlighting the great therapeutic potential of ferroptosis regulation in tumor therapy.This review is focused on the current research progress of ferroptosis in malignant tumors of the digestive system,and has summarized the roles of ferroptosis-related molecules and signaling pathways in the development of malignant tumors of the digestive system as well as the therapeutic application and research progress of ferroptosis-related drugs in the treatment of malignant tumors of the digestive system.Finally,future research directions and currently unresolved issues of ferroptosis in tumors were discussed,aiming to strengthen the theoretical basis for the important roles of ferroptosis in tumors of the digestive system from different perspectives,provide new ferroptosis-related therapeutic options for malignant tumors of the digestive system,and point out directions for further translational research.