儿童及青少年分化型甲状腺癌远处转移的特征及治疗的研究进展

Distant metastases from differentiated thyroid carcinoma in children and young adolescents:progress in characteristics and treatment

儿童及青少年分化型甲状腺癌(children and young adolescents differentiated thyroid carcinoma,CAYA-DTC)的临床特征及长期预后均与成人有较大差异,其特征为淋巴结及远处转移发生率高、复发率高而长期预后较好。以往文献报道,CAYA-DTC远处转移发生率为5%~42%,其较高的远处转移发生率使CAYA-DTC远处转移的研究一直备受关注。本文对近10年的相关研究进行回顾,阐述CAYA-DTC远处转移的临床特征、基因突变背景和治疗进展。

Children and young adolescents differentiated thyroid cancer(CAYA-DTC)is quite different from adults in terms of clinical features and long-term prognosis,with high incidence rates of lymph node and distant metastasis and recurrence,but good long-term prognosis.Previous studies have shown that the incidence rate of distant metastases in CAYA-DTC ranges from 5%to 42%.The high incidence rate of distant metastases in CAYA-DTC has made it always attract attention.Consequently,this paper reviews the related researches in the past ten years,and the clinical characteristics,gene mutation background and treatment progress in distant metastasis of CAYA-DTC are discussed.