南昌地区肺癌的发病因素——125例肺癌病例对照研究

A RESEARCH INTO THE ETIOLOGICAL FACTORS OF LUNG CANCER IN NANCHANG DISTRICT

肺癌与多种致癌因素有关,南昌市在肺癌死因回顾调查中,其标化死亡率为12.5/10万。本文采用对照研究方法对肺癌的发病因素进行探讨,重点讨论吸烟同慢支与肺癌的交互联系。

This is a report of a matched study on lung cancer carried out in eight large hospitalsin Nanchang during January-July 1984.The aim was to investigate the possible etiologicalfactors of lung cancer with the emphasis on its relation with smoking,and the cor-relation with chronic bronchitis.Among 250 inpatients,125 cases of lung cancer and 125controls were interviewed.They were matched with age,sex,occupation and races.Thesex ratio was 4 male:1 female.The average age of males was 55.1 and of femalo was 65.8.The highest age group ranged from 60-69.There was a significant difference in rcsi-dence time between the 2 groups aged 55-64.The difference between mate smokers andnon-smokers was significant,and smoking showed a highly significant dose-responserelationship.The interval between the beginning of smoking and the diagnosis of lungcancer was 40 years.Chronic bronchitits is siginificantly related with lung cancer,but smoking is even more significant,when correlatedly compare.The risk of lung cancerfor the smokers with positive family history was six times higher than the non-smokerswithout positive family history.Therefore,the preventive measure of lung cancer is notonly to raise a camparing against smokering but also to strenthen etiological researchesincluding genetic engineering.