微创颅内血肿清除术与安宫牛黄丸联合治疗高血压脑干出血的疗效

Efficacy of Minimally Invasive Intracranial Hematoma Removal Operation Combined with Angong Niuhuang Pills in the Treatment of Hypertensive Brainstem Hemorrhage

目的:探讨微创颅内血肿清除术联合安宫牛黄丸治疗高血压脑干出血的疗效及对患者神经功能的影响。方法:选择2014年2月—2018年10月我院收治的高血压脑干出血患者120例,按随机数字表法分为对照组和观察组,各60例。对照组给予微创颅内血肿清除术治疗,观察组在对照组基础上联合安宫牛黄丸治疗,两组治疗28 d后比较两组疗效、神经功能、炎症因子及预后。结果:治疗后观察组美国国立卫生研究院卒中量表(NIHSS)、CSS评分低于对照组,简易智力状态检查量表(MMSE)评分高于对照组,差异有统计学意义(P<0.05);治疗后观察组肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6、超敏C反应蛋白(hs-CRP)水平低于对照组,差异有统计学意义(P<0.05);治疗后观察组痊愈、显著进步率高于对照组,植物生存及死亡率低于对照组,差异有统计学意义(P<0.05)。结论:微创颅内血肿清除术联合安宫牛黄丸治疗高血压脑干出血患者有助于改善患者神经功能,降低炎症因子水平,且预后良好,值得推广应用。

Objective:To explore the effect of minimally invasive intracranial hematoma removal operation combined with angong niuhuang pills on hypertensive brainstem hemorrhage and its effect on patients’neurological function.Methods:120 patients with hypertensive brainstem hemorrhage admitted to our hospital from February 2014 to October 2018 were selected and randomly divided into a control group and an observation group,60 cases each.The patients in the control group were treated with minimally invasive intracranial hematoma removal operation,and the patients in the observation group were further treated with angong niuhuang pills.After 28 days of treatment,the efficacy,neurological function,inflammatory factors and prognosis were compared between the two groups.Results:After treatment,the National Institutes of Health Stroke Scale(NIHSS)and CSS scores in the observation group were lower than those in the control group,while the Mini-Mental State Examination Scale(MMSE)score was higher than that in the control group,with statistically significant differences(P<0.05).After treatment,the levels of tumor necrosis factor(TNF)-α,interleukin(IL)-6 and high-sensitivity C-reactive protein(hs-CRP)in the observation group were lower than those in the control group,with statistically significant differences(P<0.05).After treatment,the cure rate and significant progress rate in the observation group were higher than those in the control group,and the plant survival rate and mortality rate were lower than those of the control group,with statistically significant differences(P<0.05).Conclusion:Minimally invasive intracranial hematoma removal operation combined with angong niuhuang pills can help improve the neurological function of the patients with hypertensive brainstem hemorrhage and reduce the levels of inflammatory factors,and has good prognosis,which is worth popularizing.