宫颈癌患者血清甲状腺激素和甲状腺过氧化物酶抗体检测水平及临床意义

Detection of serum thyroid hormone and thyroid peroxidase antibody levels in patients with cervical cancer and its clinical significance

目的:检测宫颈癌患者血清甲状腺激素和甲状腺过氧化物酶抗体(TPO-Ab)水平,并分析其对宫颈癌患者预后的影响。方法:选取2014年1月—2015年5月我院收治的宫颈癌患者58例为研究组,选取同期我院收治的宫颈炎患者50例作为对照组,比较两组血清三碘甲状腺原氨酸(T3)、四碘甲状腺原氨酸(T4)、游离三碘甲状腺原氨酸(FT3)、游离四碘甲状腺原氨酸(FT4)、促甲状腺激素(TSH)、TPO-Ab水平,分析研究组血清T3、TPO-Ab水平与临床特征的关系以及对患者3年存活情况的影响。结果:研究组血清T3、T4、FT3、FT4水平低于对照组,差异有统计学意义(P<0.05);研究组血清TSH水平、TPO-Ab水平阳性率高于对照组,差异有统计学意义(P<0.05);宫颈癌患者血清T3水平、TPO-Ab阳性率与临床分期、淋巴结转移、肿瘤大小有关(P<0.05);血清T3低表达组3年总生存率低于T3高表达组,差异有统计学意义(P<0.05);血清TPO-Ab阴性患者3年总生存率高于阳性患者,差异有统计学意义(P<0.05)。结论:血清T3、TPO-Ab可作为宫颈癌预后的生物标记。

Objective:To detect the levels of serum thyroid hormones and thyroid peroxidase antibody(TPOAb)in patients with cervical cancer and analyze their effect on the prognosis of the patients with cervical cancer.Methods:58 patients with cervical cancer admitted to our hospital from January 2014 to May 2015 were selected as a study group,and 50 patients with cervical inflammation admitted to our hospital during the same period were selected as a control group.The levels of serum triiodothyronine(T3),tetraiodothyronine(T4),free triiodothyronine(FT3),free tetraiodothyronine(FT4),thyrotropin(TSH)and TPO-Ab were compared between the two groups.The relationship between serum T3 and TPO Ab levels and clinical characteristics,as well as the effect on the 3-year survival rate of the patients in the study group were analyzed.Results:The levels of serum T3,T4,FT3 and FT4 in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The positive rates of serum TSH and TPO-Ab levels in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The positive rates of serum T3 and TPO-Ab levels in the patients with cervical cancer were related with clinical stage,lymph node metastasis,and tumor size(P<0.05).The 3-year overall survival rate of the patients in the low serum T3 expression group was lower than that in the high serum T3 expression group,and the difference was statistically significant(P<0.05).The 3-year overall survival rate of the patients in serum TPO-Ab-negative patients was lower than that in the positive patients,and the difference was statistically significant(P<0.05).Conclusion:Serum T3 and TPO-Ab can be used as biomarkers for the prognosis of cervical cancer.