替加环素联合头孢哌酮/舒巴坦治疗泛耐药鲍曼不动杆菌肺炎的效果及对微生物清除率、28 d病死率的影响

Effect of Tigecycline Combined with Cefoperazone/Sulbactam on Pan-drug Resistant Acinetobacter Baumannii Pneumonia and Its Effect on Microbial Clearance and 28-day Mortality

目的:探讨替加环素联合头孢哌酮/舒巴坦治疗泛耐药鲍曼不动杆菌肺炎的效果及对微生物清除率、28 d病死率的影响。方法:选取2015年6月—2018年6月我院收治的泛耐药鲍曼不动杆菌肺炎患者82例为研究对象,按随机数字表法分为对照组和观察组,各41例。对照组采用头孢哌酮/舒巴坦(3 g,q8 h)治疗,观察组在对照组基础上联合替加环素(50 mg,bid)治疗。比较两组临床疗效、病原菌清除率及28 d病死率。结果:观察组总有效率高于对照组,差异有统计学意义(P<0.05);治疗后观察组微生物总清除率高于对照组,28 d病死率低于对照组,差异有统计学意义(P<0.05)。结论:替加环素联合头孢哌酮/舒巴坦治疗泛耐药鲍曼不动杆菌肺炎的疗效明确,可在提高微生物清除率同时降低28 d病死率。

Objective:To investigate the effect of tigecycline combined with cefoperazone/sulbactam on pan-drug resistant acinetobacter Baumannii pneumonia and its effect on microbial clearance and 28-day mortality.Methods:82 patients with pan-drug resistant acinetobacter Baumanmi pneumonia admitted to our hospital from June 2015 to June 2018 were selected as subjects investigated,and they were randomly divided into a control group and an observation group,41 cases each.The patients in the control group were treated with cefoperazone/sulbactam(3 g,q8 h),and the patients in the observation group were further treated with tigecycline(50 mg,bid).The clinical efficacy,pathogen removal rate and 28-day mortality were compared between the two groups.Results:The total effective rate in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the total microbial clearance rate in the observation group was higher than that in the control group,and the 28-day mortality was lower than that in the control group,with statistically significant differences(P<0.05).Conclusion:Tigecycline combined with cefoperazone/sulbactam has a clear therapeutic effect on Pan-drug resistant acinetobacter Baumannii pneumonia,which can increase the microbial clearance and reduce the 28-day mortality.