酚妥拉明联合多巴胺治疗小儿重症肺炎疗效及对炎症因子、肺表面活性蛋白水平的影响

Efficacy of Phentolamine Combined with Dopamine in the Treatment of Pediatric Severe Pneumonia and Its Effect on Levels of Inflammatory Factors and Pulmonary Surfactant Proteins

目的:探究酚妥拉明联合多巴胺治疗小儿重症肺炎的疗效及对患者炎症因子、肺表面活性蛋白水平的影响。方法:选取2016年7月—2018年7月我院收治的重症肺炎患儿180例,按随机数字表法分为研究组和对照组,各90例。对照组予以常规抗菌药治疗,在此基础上,研究组加用酚妥拉明(0.3~0.5 mg)联合盐酸多巴胺注射液(0.5μg)治疗。比较两组临床疗效、炎症因子和肺表面活性蛋白水平。结果:治疗后,研究组C反应蛋白(CRP)水平、肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6水平低于对照组,IL-10水平高于对照组,差异有统计学意义(P<0.05);研究组肺表面活性蛋白(SP-A、SP-B、SP-C、SP-D)水平低于对照组,差异有统计学意义(P<0.05);研究组总有效率高于对照组,差异有统计学意义(P<0.05)。结论:酚妥拉明联合多巴胺治疗小儿重症肺炎的疗效显著,可有效缓解机体炎症反应,降低肺表面活性蛋白水平,值得临床推荐。

Objective:To investigate the efficacy of phentolamine combined with dopamine in the treatment of pediatric severe pneumonia and its effect on the levels of in?ammatory factors and pulmonary surfactant proteins.Methods:180 children with severe pneumonia admitted to our hospital from July 2016 to July 2018 were selected and randomly divided into a study group and a control group,90 cases each.The children in the control group were treated with conventional antibacterial.On this basis,the children in the study group were treated with phentolamine(0.3~0.5 mg)combined with dopamine hydrochloride injection(0.5μg).The clinical efficacy and the levels of inflammatory factors and pulmonary surfactant proteins were compared between the two groups.Results:After treatment,the levels of C-reactive protein(CRP),tumor necrosis factor(TNF)-αand interleukin(IL)-6 in the study group were lower than those in the control group,while the level of IL-10 was higher than that in the control group,which statistically significant differences(P<0.05).The levels of pulmonary surfactant proteins(SP-A,SP-B,SP-C,SP-D)in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The total effective rate in the study group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:Phentolamine combined with dopamine is significantly effective in the treatment of pediatric severe pneumonia,which can effectively alleviate in?ammatory response in the children and reduce the levels of surfactant proteins in lungs,and is worthy of clinical recommendation.