醋酸曲普瑞林与人绒毛膜促性腺激素对多囊卵巢综合征患者排卵质量的影响

Effect of Triptorelin Acetate and Human Chorionic Gonadotropin on Ovulation Quality in Patients with Polycystic Ovary Syndromes

目的:观察醋酸曲普瑞林与人绒毛膜促性腺激素(hCG)对多囊卵巢综合征(PCOS)患者排卵质量的影响。方法:选择我院2016年1月—2018年1月收治的70例PCOS患者,应用随机数字表法分为观察组与对照组,各35例。卵泡成熟日对照组接受hCG(6000~10000 IU)诱导排卵,观察组接受醋酸曲普瑞林(0.1 mg)诱导排卵。观察两组排卵质量、妊娠情况及黄体血流分级。结果:两组子宫内膜厚度、成熟卵泡数目、排卵率、妊娠率、未破裂卵泡黄素化综合征(LUFS)发生率、早期妊娠流产率、黄体血流分级比较,差异无统计学意义(P>0.05);观察组优势卵泡数目多于对照组,卵巢过度刺激综合征(OHSS)发生率低于对照组,差异有统计学意义(P<0.05)。结论:醋酸曲普瑞林用于PCOS治疗中,利于提升排卵质量,降低OHSS发生风险,改善妊娠结局。

Objective:To observe the effect of triptorelin acetate and human chorionic gonadotropin(hCG)on ovulation quality in patients with polycystic ovary syndromes(PCOS).Methods:70 patients with PCOS admitted to our hospital from January 2016 to January 2018 were randomly divided into an observation group and a control group,35 cases each.On the day of follicular maturation,the patients in the control group received hCG(6000 to 10000 IU)to induce ovulation,and the patients in the observation group received triptorelin acetate(0.1 mg)to induce ovulation.The ovulation quality,pregnancy status and luteal blood?ow grading in the two groups were observed.Results:The differences in endometrial thickness,number of mature follicles,ovulation rate,pregnancy rate,incidence of unruptured follicular luteinization syndrome(LUFS),early pregnancy abortion and luteal blood?ow grading were not statistically significant(P>0.05).The number of dominant follicles in the observation group was higher than that in the control group,while the incidence of ovarian hyperstimulation syndrome(OHSS)was lower than that in the control group,with statistically significant differences(P<0.05).Conclusion:Triptorelin acetate is used in the treatment of PCOS,which can help to improve quality of ovulation,reduce the risk of OHSS and improve pregnancy outcomes.