醋酸甲羟孕酮对产后子宫内膜炎患者子宫内膜厚度及症状缓解情况的影响分析

Analysis on Effect of Medroxyprogesterone Acetate on Endometrial Thickness and Symptom Remission in Patients with Postpartum Endometritis

目的:分析醋酸甲羟孕酮对产后子宫内膜炎患者子宫内膜厚度及症状缓解情况的影响。方法:选择2015年1月—2018年1月我院收治的子宫内膜炎患者90例,按随机数字表法分为对照组与观察组,各45例。对照组给予常规治疗,观察组在对照组基础上给予醋酸甲羟孕酮片(2 mg,qd)治疗,21 d为一个疗程,两组均治疗2个疗程,随访3个月。比较两组治疗前后炎症因子水平,生活质量及临床病症改善时间、子宫内膜厚度、不良反应发生率、复发率。结果:治疗后,观察组白细胞介素(IL)-1、肿瘤坏死因子(TNF)-α均低于对照组,IL-2高于对照组,差异有统计学意义(P<0.05);治疗后,观察组临床病症改善时间短于对照组,子宫内膜厚度小于对照组,差异有统计学意义(P<0.05);干预后,观察组生活质量评分高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率及复发率比较,差异无统计学意义(P>0.05)。结论:醋酸甲羟孕酮治疗产后子宫内膜炎的疗效显著,可减少患者的子宫内膜厚度,缩短病症改善时间。

Objective:To analyze the effect of medroxyprogesterone acetate on endometrial thickness and symptom remission in patients with postpartum endometritis.Methods:90 patients with endometritis admitted to our hospital from January 2015 to January 2018 were selected and randomly divided into a control group and an observation group,45 cases each.The patients in the control group were given conventional treatment,and the patients in the observation group were further treated with medroxyprogesterone acetate tablets(2 mg,qd),21 days as a course of treatment.The patients in the two groups were treated for 2 courses and followed up for 3 months.The levels of inflammatory factors,quality of life,the improvement time of clinical symptoms,endometrial thickness,the incidence of adverse reactions and recurrence rate were compared between the two groups.Results:After treatment,the levels of interleukin(IL)-1 and tumor necrosis factor(TNF)-αin the observation group were lower than those in the control group,while the level of IL-2 was higher than that in the control group,with statistically significant differences(P<0.05).After treatment,the improvement time of clinical symptoms in the observation group was shorter than that in the control group,and the endometrial thickness was smaller than that in the control group,with statistically significant differences(P<0.05).After the intervention,the score of quality of life in the observation group was higher than that in the control group,with statistically significant difference(P<0.05).There were no statistically significant differences in the incidence of adverse reactions and recurrence rate between the two groups(P>0.05).Conclusion:Medroxyprogesterone acetate is significantly effective in thetreatment of postpartum endometritis,which can reduce the endometrial thickness of the patients and shorten the improvement time of the disease.