内镜下肾上腺素注射治疗对非静脉曲张性上消化道出血患者止血效果的影响

Hemostatic Effect of Endoscopic Adrenaline Injection on Patients with Nonvariceal Upper Gastrointestinal Bleeding

目的:探讨内镜下肾上腺素注射治疗非静脉曲张性上消化道出血(NVUGIB)的止血效果。方法:选取我院2016年3月—2018年3月收治的NVUGIB患者100例,根据随机数字表法分为对照组与观察组,各50例。全部患者入院后均接受常规治疗,对照组在此基础上接受内镜下金属钛夹止血,观察组接受内镜下金属钛夹联合肾上腺素注射治疗,比较两组止血效果、血红蛋白水平及安全性。结果:观察组首次止血率、有效止血率均高于对照组,再出血率低于对照组,平均钛夹使用枚数少于对照组,差异有统计学意义(P<0.05);治疗第3 d、治疗第7 d,两组血红蛋白水平均较入院时提高,且观察组高于对照组,差异有统计学意义(P<0.05);两组均无严重并发症与不良反应发生。结论:内镜下肾上腺素注射治疗NVUGIB,利于减少金属钛夹的使用,增强止血效果,提高患者的血红蛋白水平,且安全性高。

Objective:To investigate the hemostatic effect of endoscopic adrenaline injection on non-variceal upper gastrointestinal bleeding(NVUGIB).Methods:100 patients with NVUGIB admitted to our hospital from March 2016 to March 2018 were selected and randomly divided into a control group and an observation group,50 cases each.All patients received conventional treatment after admission.The patients in the control group received endoscopic metal titanium clip treatment to stop bleeding,and the patients in the observation group received endoscopic metal titanium clip treatment combined with adrenaline injection.The hemostatic effect,hemoglobin level and safety were compared between the two groups.Results:The first hemostatic rate and effective hemostatic rate in the observation group were higher than those in the control group,while the rebleeding rate was lower than that in the control group,and the average number of titanium clips used was lower than that in the control group,with statistically significant differences(P<0.05).The level of hemoglobin on the 3 rd day of treatment and the 7 th day of treatment was higher than that at the time of admission in the two groups,and the level in the observation was higher than that in the control group,with statistically significant differences(P<0.05).There were no serious complications and adverse reactions in the two groups.Conclusion:Endoscopic adrenaline injection for treating NVUGIB can help to reduce the use of metal titanium clips,enhance hemostatic effect and improve the level of hemoglobin,and is safe.