术前强化阿托伐他汀治疗改善择期PCI术后患者无复流现象及心功能的效果分析

Analysis on Improving Effect of Preoperative Intensive Atorvastatin Treatment on No-reflow Phenomenon and Cardiac Functions in Patients Undergoing Elective PCI

目的:探讨术前强化阿托伐他汀治疗对择期冠状动脉介入性治疗(PCI)患者的应用效果。方法:选择2016年7月—2018年1月我院收治的90例择期行PCI术患者为研究对象,按随机数字表法分为两组,各45例。术前,对照组采用常规剂量阿托伐他汀(20 mg,qd)治疗,观察组采用强化阿托伐他汀(80 mg,qd)治疗,比较两组心功能指标、校正的TIMI帧数(CTFC)、无复流发生率。结果:术后1个月,观察组左室舒张末容积指数(LVEDVI)、左室收缩末容积指数(LVESVI)值均低于对照组,左室射血分数(LVEF)值高于对照组,差异有统计学意义(P<0.05);观察组左回旋支、左前降支、右冠脉血管CTFC均低于对照组,差异有统计学意义(P<0.05);两组无复流发生率比较,差异无统计学意义(P>0.05)。结论:择期PCI术前,采用强化阿托伐他汀治疗,可有效调节患者的微血管循环,改善术后心功能指标,减少无复流现象。

Objective:To investigate the effect of preoperative intensive atorvastatin on patients undergoing elective coronary intervention(PCI).Methods:90 patients who underwent elective PCI in our hospital from July 2016 to January 2018 were selected as subjects investigated,and they were randomly divided into two groups:a control group and a observation group,45 cases each.The patients in the control group were treated with conventional dose of atorvastatin(20 mg,qd)before operation,and the patients in the observation group were treated with intensive atorvastatin(80 mg,qd).The cardiac function indexes,the number of corrected TIMI frames(CTFC)and the incidence of no-reflow were compared between the two groups.Results:One month after operation,the values of left ventricular end-diastolic volume index(LVEDVI)and the left ventricular end-systolic volume index(LVESVI)in the observation group were lower than those in the control group,while the value of left ventricular ejection fraction(LVEF)was higher than that in the control group,with statistically significant differences(P<0.05).The CTFC of left circumflex branch,left anterior descending branch and right coronary artery in the observation group was lower than that in the control group,with statistically significant differences(P<0.05).There was no statistically significant difference in the incidence of no-reflow between the two groups(P>0.05).Conclusion:Intensive atorvastatin therapy before the elective PCI can effectively regulate the microvascular circulation of the patients,improve postoperative cardiac function indexes and reduce no-reflow phenomenon.