罗哌卡因复合帕瑞昔布钠对颅脑肿瘤切除术患者应激反应及苏醒质量的影响

Effect of Ropivacaine Combined with Parecoxib Sodium on Stress Response and Recovery Quality in Patients Undergoing Brain Tumor Resection

目的:探讨罗哌卡因复合帕瑞昔布钠对颅脑肿瘤切除术患者应激反应及苏醒质量的影响。方法:选择2017年7月—2019年7月我院收治的颅脑肿瘤拟行切除术患者84例,按随机数字表法分为对照组和观察组,各42例,两组均给予常规麻醉诱导和麻醉维持,对照组在切皮前10 min给予0.9%氯化钠注射液(20 mL)浸润麻醉,术后30 min注射0.9%氯化钠注射液(2 mL);观察组在切皮前10 min给予罗哌卡因(20 mL)麻醉,术后30 min注射帕瑞昔布钠(40 mg),比较两组应激反应及苏醒质量。结果:T2时,观察组心率、平均动脉压均低于对照组,差异有统计学意义(P <0.05);观察组苏醒时间、拔管时间均短于对照组,Ramsay评分、视觉模拟评分法(VAS)评分低于对照组,差异有统计学意义(P <0.05)。结论:罗哌卡因复合帕瑞昔布钠可减轻颅脑肿瘤切除术患者应激反应,可提高镇静、镇痛效果,改善苏醒质量。

Objective:To investigate the effect of ropivacaine combined with parecoxib sodium on stress response and recovery quality in patients with brain tumor resection. Methods:84 patients undergoing brain tumor resection admitted to our hospital from July 2017 to July 2019 were selected and randomly divided into a control group and an observation group, 42 cases each. The patients in the two groups were given conventional anesthesia induction and anesthesia maintenance. The patients in the control group were given 0.9% sodium chloride injection(20 mL) infiltration anesthesia 10 minutes before skin incision and 0.9% sodium chloride injection(2 mL) 30 minutes after operation. The patients in the observation group were anesthetized with ropivacaine(20 mL) 10 minutes before skin incision and given parecoxib sodium(40 mg) by injection 30 minutes after skin incision. The stress response and recovery quality were compared between the two groups. Results:At T2, the heart rate and mean arterial pressure in the observation group were lower than those in the control group, and the differences were statistically significant(P<0.05). The recovery time and extubation time in the observation group were shorter than those in the control group, and the Ramsay score and visual analog scale(VAS) score were lower than those in the control group, with statistically significant differences(P<0.05). Conclusion:Ropivacaine combined with parecoxib sodium can alleviate the stress response in the patients undergoing brain tumor resection, improve sedative and analgesic effects and improve the quality of recovery.