痰热清注射液联合布地奈德对支原体肺炎患儿炎症因子及免疫球蛋白水平的影响

Effect of Tanreqing Injection Combined with Budesonide on Inflammatory Factors and Immunoglobulin Levels in Children with Mycoplasmal Pneumonia

目的:探究痰热清注射液联合布地奈德对支原体肺炎(MPP)患儿炎症因子及免疫球蛋白水平的影响。方法:选取2017年6月—2018年3月我院收治的MPP患儿108例,按照治疗方案的不同分为治疗组与对照组,各54例。对照组单纯给予布地奈德(100μg,bid,雾化吸入)治疗,治疗组在此基础上加用痰热清注射液(0.3~0.5 mL/kg,ivgtt,qd)治疗,均连续治疗2周。比较两组临床疗效、复发情况,以及两组治疗前炎症因子及免疫球蛋白水平。结果:治疗后,两组白细胞介素(IL)-2、IL-4均高于治疗前,且治疗组高于对照组,差异有统计学意义(P<0.01);两组干扰素(IFN)-γ、肿瘤坏死因子(TNF)-α均低于治疗前,且治疗组低于对照组,差异有统计学意义(P<0.01);治疗后,治疗组免疫球蛋白(Ig)G高于对照组,IgA、IgM低于对照组,差异有统计学意义(P<0.01);治疗组总有效率高于对照组,差异有统计学意义(P<0.05);治疗组复发率低于对照组,差异有统计学意义(P<0.05)。结论:痰热清注射液联合布地奈德治疗MPP患儿的疗效显著,可有效改善患儿炎症状态及免疫功能,且预后良好,值得临床推广。

Objective:To investigate the effect of tanreqing combined with budesonide on inflammatory factors and immunoglobulin levels in children with mycoplasmal pneumonia(MPP).Methods:108 children with MPP admitted to our hospital from June 2017 to March 2018 were selected and divided into a treatment group and a control group according to different treatment regimens,54 cases each.The patients in the control group were treated with budesonide alone(100μg,bid,nebulized inhalation),and the patients in the treatment group were treated with tanreqing injection(0.3~0.5 mL/kg,ivgtt,Qd).The patients in the two groups were continuously treated for 2 weeks.The clinical efficacy,recurrence and the levels of inflammatory factors and immunoglobulin before treatment were compared between the two groups.Results:The levels of interleukin(IL)-2 and IL-4 after treatment were higher than those before treatment in the two groups,and the levels in the treatment group were higher than those in the control group,with statistically significant differences(P<0.01).The levels of interferon(IFN)-γand tumor necrosis factor(TNF)-αafter treatment were lower than those before treatment in the two groups,and the levels in the treatment group were lower than those in the control group,with statistically significant differences(P<0.01).After treatment,the level of immunoglobulin(Ig)G in the treatment group was higher than that in the control group,while the levels of IgA and IgM were lower than those in the control group,with statistically significant differences(P<0.01).The total effective rate in the treatment group was higher than that in the control group,and the difference was statistically significant(P<0.05).The recurrence rate in the treatment group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:Tanreqing combined with budesonide has a significant therapeutic effect on MPP in children,which can effectively improve the inflammatory state and immune function of the children,and is good in prognosis and worthy of clinical promotion.