苇茎汤加味对百日咳综合征患儿潮气呼吸肺功能及炎症因子的影响

Effects of Jiawei Weijing Decoction(苇茎汤加味)on Tidal Breathing Lung Function and Inflammatory Factors in Child Patients with Pertussis Syndrome

目的:探究苇茎汤加味对百日咳综合征患儿潮气呼吸肺功能及炎症因子水平的影响。方法:选择我院收治的84例百日咳综合征患儿,随机分为对照组和观察组各42例,对照组给予常规西医治疗,在此基础上,观察组加用苇茎汤加味治疗,分析两组患儿疗效、中医证候、潮气呼吸肺功能、炎症因子差异。结果:观察组患儿治疗总有效率明显高于对照组(P<0.05)。与治疗前比较,两组治疗后的中医证候(痉咳频次、痉咳时间、呕吐、痰鸣、憋喘、气促)积分均显著降低(P<0.01);治疗后,观察组各项中医证候积分均显著低于对照组(P<0.01)。与治疗前比较,两组治疗后的潮气呼吸肺功能[潮气量(VT)、吸气呼气时间比(Ti/Te)、达峰时间比(TPTEF/TE)、达峰容积比(VPEF/VE)]均显著升高(P<0.01),呼吸频率(RR)、呼吸系统阻力(Rrs)均显著降低(P<0.01);治疗后,观察组的VT、Ti/Te、TPTEF/TE、VPEF/VE显著高于对照组(P<0.01),RR、Rrs显著低于对照组(P<0.05)。与治疗前比较,两组治疗后的炎症因子[白细胞介素-4(IL-4)、IL-6、干扰素γ(INF-γ)、肿瘤坏死因子-α(TNF-α)]水平均显著降低(P<0.01);治疗后,观察组各炎症因子水平均显著低于对照组(P<0.01)。两组患儿治疗期间均未出现严重不良反应。结论:苇茎汤加味治疗百日咳综合征疗效确切,在改善患儿潮气呼吸肺功能、降低炎症因子及提高免疫力方面具有明显优势。

Objective:To explore the effects of Jiawei Weijing Decoction(苇茎汤加味)on tidal breathing lung function and inflammatory factors in child patients with pertussis syndrome.Methods:Eighty-four child patients with pertussis syndrome treated in the Henan Provincial Hospital of Traditional Chinese Medicine were enrolled and randomly divided into a control group and an observation group,with 42 cases in each group.Patients in the control group received conventional western medicine treatment,while those in the observation group were treated with Jiawei Weijing Decoction additionally on the basis of the therapeutic protocol of the control group.The differences of the two groups in efficacy,traditional Chinese medicine(TCM)syndromes,tidal breathing lung function,and inflammatory factors were analyzed.Results:The total effective rate in the observation group was higher than that in the control group(P<0.05).The post-treatment scores of TCM syndromes(frequency of spasmodic cough,time of spasmodic cough,vomiting,gurgling with sputum,dyspnea,and shortness of breath)were lower than those before treatment in both groups(P<0.01).After treatment,the scores of TCM syndromes of the observation group were lower than those of the control group(P<0.01).The post-treatment levels of tidal breathing lung function indexes[tidal volume(VT),inspiratory-expiratory time ratio(Ti/Te),time to peak tidal expiratory flow as a proportion of expiratory time(TPTEF/TE),and volume to peak expiratory flow as a proportion of exhaled volume(VPEF/VE)]were higher(P<0.01)and the respiratory rate(RR)and respiratory system resistance(Rrs)were lower(P<0.01)than those before treatment in both groups.After treatment,compared with the control group,the levels of VT,Ti/Te,TPTEF/TE,and VPEF/VE increased in the observation group(P<0.01),while the levels of RR and Rrs decreased(P<0.05).Compared with the results before treatment,the levels of inflammatory factors[interleukin-4(IL-4),IL-6,γinterferon(INF-γ),and tumor necrosis factor-α(TNF-α)]were reduced in both groups after treatment(P<0.01).The levels of various inflammatory factors in the observation group were lower than those in the control group after treatment(P<0.01).There were no serious adverse reactions in the two groups during treatment.Conclusion:Jiawei Weijing Decoction has a definite efficacy in treating pertussis syndrome.It has obvious advantages in improving the tidal breathing lung function,reducing inflammatory factors,and enhancing immunologic function.