血脂、血清铜及25-(OH)D3在妊娠期糖尿病患者中的水平变化及意义分析

Changes of blood lipid,serum copper and 25-(OH)D3 levels in patients with gestational diabetes mellitus and their significance analysis

目的探讨血脂、血清铜及25-(OH)D3在妊娠期糖尿病(GDM)患者中的水平变化及意义分析,为孕妇GDM的预防与治疗提供依据。方法收集我院2016年2月~2017年6月1362例入院分娩患者临床资料;选取GDM 398例为研究组,同时选取正常足月妊娠妇女400例作为对照;分析两组孕妇临床资料及血脂、血清铜及25-(OH)D3水平变化及意义。结果通过对比两组临床资料发现,研究组孕妇年龄、BMI、甘油三脂、胆固醇、血清铜及糖尿病家族史明显高于对照组(P<0.05),而血清25-(OH)D3、钙、铁、锌都明显较低(P<0.05);BMI、甘油三酯、胆固醇、血清铜含量高、血清25-(OH)D3含量低及糖尿病家族史是孕妇发生GDM的独立危险因素;血脂、血清铜与GDM患者血糖水平呈正相关,血清25-(OH)D3与GDM患者血糖呈负相关。结论孕妇发生GDM的危险因素有甘油三酯、胆固醇、糖尿病家族史、血清铜,血脂、血清铜及血清25-(OH)D3与孕妇血糖水平具有相关性,在孕育糖尿病的预防中具有一定的指导作用。

Objective:To investigate the changes and significance of serum lipids,serum copper and 25-(OH)D3 in patients with gestational diabetes mellitus(GDM),and to provide evidence for the prevention and treatment of GDM in pregnant women.Methods:The clinical data of 1362 patients admitted to hospital from February 2016 to June 2017 were collected.398 GDM patients were selected as the study group,and 400 normal pregnant women were selected as controls.The clinical data of the two groups of pregnant women and the changes and significance of serum lipids,serum copper and 25-(OH)D3 levels were analyzed.Results:By comparing the clinical data of the two groups,the age,BMI,education level,triglyceride,cholesterol,serum copper and diabetes family history of the study group were significantly higher than the control group(P<0.05),while serum 25-(OH)D3,iron and zinc were significantly lower(P<0.05);BMI,triglyceride,cholesterol,serum copper content,serum 25-(OH)D3 content and family history of diabetes were independent risk factors for GDM in pregnant women.Blood lipids and serum copper were positively correlated with blood glucose levels in patients with GDM,and serum 25-(OH)D3 was negatively correlated with blood glucose in patients with GDM.Conclusion:The risk factors for GDM in pregnant women are BMI,triglyceride,cholesterol,serum 25-(OH)D3,family history of diabetes,and blood lipids,serum copper and serum 25-(OH)D3 are related to blood glucose levels in pregnant women.It has a certain guiding role in the prevention of diabetes.