胎盘组织中Eph A5表达水平与前置胎盘患者血清妊娠结局的意义

目的探讨胎盘组织中Eph A5表达水平及前置胎盘患者血清与妊娠结局的关系。方法以本院96例待产前置胎盘患者为研究对象,根据不同前置胎盘类型分为不同组别,同期按照孕周配比选取30例确诊为正常的待产孕妇为对照组。收集两组确诊时血标本及产后胎盘组织,对比两组研究对象血清及胎盘组织中Eph A5水平,并分析观察组内不同类型前置胎盘中的表达差异;随访两组母婴妊娠结局发生情况并进行比较,同时根据观察组妊娠结局是否良好分为良好组与不良组,比较两组Eph A5水平。结果观察组血清及胎盘组织中Eph A5水平依次为(2.57±0.21)pmol/L、(0.82±0.09),均显著低于对照组(14.87±1.46)pmol/L、(2.84±0.28)(P<0.05);观察组前置胎盘完全型患者、部分型患者、边缘型患者的血清及胎盘组织中Eph A5水平比较,差异均无统计学意义(P>0.05);两组产后出血率、助产使用率均无统计学意义(P>0.05),但观察组的剖宫产率47.92%、宫内窘迫率27.08%均显著高于对照组10.0%、0%,其新生儿Apgar评分(8.2±1.1)分、新生儿体重(3310.5±412.3)g则显著低于对照组(8.8±1.1)分、(3553.7±404.7)g(P<0.05);结局不良组血清Eph A5、胎盘组织Eph A5相对表达量依次为(2.14±0.21)pmol/L、(0.81±0.07),均显著低于结局良好组(2.73±0.25)pmol/L、(0.88±0.08)(P<0.05)。结论PP患者血清及胎盘组织中Eph A5表达水平低下,不利于母婴结局。

Objective:To explore relationship between expression level of Eph A5 and pregnancy outcomes in serum and placenta tissues of patients with placenta previa(PP).Methods:96 awaiting delivery patients with PP in the hospital were enrolled in this study.According to different PP types,they were divided into different groups.In the same period,30 normal pregnant women were enrolled as control group.Blood samples and postpartum placenta tissues at diagnosis time were collected.The level of Eph A5 in serum and placenta tissues was compared between the two groups.The expression differences in different types of PP were analyzed and observed.The occurrence of maternal and fetal pregnancy outcomes in both groups was followed up and compared.According to different pregnancy outcomes in observation group,they were divided into good group and poor group.Eph A5 level was compared between the two groups.Results:The levels of Eph A5 in serum and placenta tissues of observation group were(2.57±0.21)pmol/L and(0.82±0.09),which were significantly lower than those in control group[(14.87±1.46)pmol/L,(2.84±0.28)](P<0.05).In observation group,there was no significant difference in Eph A5 level in serum and placenta tissues among patients with complete PP,partial PP,and marginal PP(P>0.05).There was no significant difference in postpartum hemorrhage rate or accouche utilization rate between the two groups(P>0.05).The cesarean section rate and intrauterine distress rate in observation group were significantly higher than those in control group(47.92%,27.08%vs 10.0%,0%),while neonatal Apgar score and neonatal weight were significantly lower than those in control group[(8.2±1.1)points,(3310.5±412.3)g vs(8.8±1.1)points,(3553.7±404.7)g](P<0.05).The relative expression quantities of Eph A5 in serum and placenta tissues of poor outcome group were significantly lower than those of good outcome group[(2.14±0.21)pmol/L,(0.81±0.07)vs(2.73±0.25)pmol/L,(0.88±0.08)](P<0.05).Conclusion:The expression level of Eph A5 in serum and placenta tissue of PP patients is low,which is not conducive to maternal and infant outcomes.