防城港地区1149例出生缺陷监测资料分析

Monitoring data of 1149 cases of birth defects in fangchenggang district

目的分析防城港出生缺陷的发生及相关因素,为研究病因提供线索,从而制定有效的干预措施。方法选取2011年1月~2018年10月防城港市医疗保健机构出生的妊娠满28w至出生后7天内的所有围产儿(包括活产儿、死胎死产儿)为监测对象。结果出生缺陷发生率为81.99/万,前5位分别是:肢端(指、趾)异常、总唇腭裂、马蹄内翻足、胎儿水肿、外耳其他畸形。发生率男婴高于女婴(P<0.05);城镇高于农村(P<0.05);<20岁组及≥35岁组高于20-34岁组(P<0.05);有显著性差异。结论本地区的出生缺陷以形态结构异常为主,发生率处于低水平,与胎儿性别、孕母年龄、居住环境等因素有关。

Objective:To analyze the occurrence and relevant factors of birth defects in Fangchenggang,and to provide clues for the study of etiology,so as to formulate effective interventions.Methods:All perinatal infants(including live infants and stillborn infants)born in Fangchenggang medical and health care institutions from January 2011 to October 2018 were selected as subjects for monitoring.Results:The incidence rate of birth defects was 81.99/10000.Among perinatal birth defects,the first five were:abnormal extremity(fingers and toes),total cleft lip and palate,varus of horseshoe foot,fetal edema,and other deformity of external ear.The incidence of male infants was higher than female infants(P<0.05).Urban was higher than rural(P<0.05).<20 years old group and≥35 years old group were higher than 20-34 years old group(P<0.05).The significant differences were emerged.Conclusion:The primary birth defects in this area were morphological and structural abnormalities,and the incidence of birth defects is at a low level,which is related to fetal sex,maternal age,residential environment etc.