红斑狼疮血管炎相关临床表现

Characterization of Lupus Vasculitis

大约50%的系统性红斑狼疮(systemic lupus erythematosus,SLE)患者在疾病过程中会出现血管炎,以小血管为受累为主,并且90%为皮肤血管炎。内脏器官血管炎虽然少见,但是重要脏器受累会危及患者生命。血管炎的出现往往意味着预后差;而因受累血管大小、部位不同,狼疮血管炎的临床表现又呈现很大的异质性,这给疾病的早期诊断和及时治疗带来很大的挑战。由此,本文对不同器官狼疮血管炎的临床表现、相关实验室和影像学检查等特点做一概述,以提高临床医生对该病的认识。

Lupus vasculitis are observed in 50% of patients with systemic lupus erythematosus(SLE), which mainly involves small blood vessels, and rarely affects large ones. Skin is the most frequent organ involved by lupus vasculitis(90%). The involvement of internal organs is rare but might lead to mortalities. Thus, early diagnosis is critical to prevent the undesired events. However, it is a great challenge for clinicians because of the clinical heterogenicity due to the size and site of the involved blood vessels. Herein, we outlined the clinical manifestations, the related-laboratory examinations and medical images to improve the basic knowledge of lupus vasculitis.