白癜风的临床与生物标志物

Clinical Markers and Biomarkers of Vitiligo

白癜风(vitiligo)是一种常见的获得性色素脱失性皮肤病,发病机制尚未完全阐明。临床根据白癜风的病期分为稳定期和进展期,采取不同的治疗方案。准确判断白癜风的病期对选择个体化治疗方案,预测疾病的转归和复发至关重要。近年来,关于白癜风病期及治疗反应性的临床与生物标志物研究取得了一系列进展,研究主要集中在临床标志物和生物标志物两方面,本文从白癜风发病机制与相关标志物的相关性总结近期研究进展,希望为临床诊断及治疗提供一定的帮助。

Vitiligo is a common acquired pigmentation disorder characterized by loss of pigmentation whose pathogenesis has not been fully elucidated.According to the clinical phase of vitiligo,it can be divided into stable and progressive vitiligo,and thus different strategies are adopted.Accurate judgement of the clinical phase of vitiligo is very important for the selection of an individualized treatment plan and prediction of disease outcome and recurrence.In recent years,researchers aiming at exploring clinical markers and biomarkers for the clinical phase and treatment response of vitiligo have made great progress.In this review,we summarize the latest progress from the perspective of the correlation between the pathogenesis of vitiligo and related markers,expecting to provide evidence for clinical diagnosis and treatment.