硝苯地平对先兆早产孕妇安胎成功率的影响

Effects of Nifedipine on the Success Rate of Miscarriage Prevention in Threatened Premature Women

目的探讨硝苯地平对先兆早产孕妇安胎成功率的影响。方法选取2018年5月至2019年5月于佛山市高明区人民医院进行保胎治疗的86例先兆早产孕妇作为研究对象,按随机数字表法分为对照组与观察组,各43例。对照组采用盐酸利托君注射液治疗,观察组采用硝苯地平片治疗,比较两组妊娠结局、药物起效时间、延长妊娠时间、新生儿体重、Apgar评分、血压水平及不良反应发生情况。结果与对照组比较,观察组新生儿体重较重,Apgar评分及保胎成功率均较高,延长妊娠时间较长,不良反应发生率较低,差异有统计学意义(P<0.05);两组孕妇治疗前后舒张压及收缩压水平比较,差异无统计学意义(P>0.05);两组孕妇药物起效时间比较,差异无统计学意义(P>0.05)。结论在先兆早产孕妇中应用硝苯地平治疗,可有效抑制宫缩,提高保胎成功率,改善新生儿质量,且不良反应少,安全性高。

Objective To explore the effects of nifedipine on the success rate of miscarriage prevention in threatened premature women.Methods From May 2018 to may 2019,86 cases of threatened premature women who were treated in Gaoming District People’s Hospital of Foshan City were selected as the study objects.They were divided into control group and observation group according to the random number table method,with 43 cases in each group.The control group was treated with ritodrine hydrochloride injection,and the observation group was treated with nifedipine tablets.The pregnancy outcome,the time of drug onset,the time of prolonged pregnancy,the weight of newborn,Apgar score,blood pressure level and adverse reactions were compared between the 2 groups.Results Compared with control group,the neonatal weight of observation group was heavier,the Apgar score and success rate of miscarriage prevention in observation group were higher,the prolonged time of pregnancy in observation group was longer,and the incidence of adverse reactions in observation group was lower(P<0.05);There was no statistical difference in the diastolic pressure and systolic pressure between 2 groups before and after treatment(P>0.05);There was no statistical difference in the onset time of drug between 2 groups(P>0.05).Conclusion Nifedipine in treatment of pregnant threatened premature women can inhibit uterine contraction,increase the success rate of miscarriage prevention,improve neonatal weight,have less adverse reactions and high safety.