利奈唑胺对重症肺炎患者血清炎症介质水平的影响

Effects of Linezolid on Serum Inflammatory Mediators in Patients with Severe Pneumonia

目的探讨利奈唑胺对重症肺炎患者血清炎症介质水平的影响。方法选取2017年3月至2019年5月北部战区总医院收治的重症肺炎患者100例作为研究对象,随机分为对照组与观察组,各50例。两组均给予一般支持疗法辅助治疗,对照组在一般支持疗法基础上采用万古霉素治疗,观察组在一般支持疗法基础上采用利奈唑胺治疗,比较两组临床疗效、血气分析指标[血氧饱和度(SaO2)、氧分压(PaO2)、氧合指数(PaO2/FiO2)]、血清炎症介质[白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)]变化、临床症状消失时间、不良反应发生情况。结果观察组治疗有效率明显高于对照组,差异有统计学意义(P<0.05);两组治疗后SaO2、PaO2、PaO2/FiO2均高于治疗前,且观察组均高于对照组,差异有统计学意义(P<0.05);两组治疗后IL-6、IL-8、TNF-α水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组患者咳嗽、发热、呼吸困难、肺部啰音消失时间均短于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论采用利奈唑胺治疗重症肺炎患者,可有效改善患者血清IL-6、IL-8、TNF-α水平及机体缺氧情况,缩短临床症状改善时间。

Objective To explore the effects of linezolid on serum inflammatory mediators in patients with severe pneumonia.Methods From March 2017 to may 2019,100 patients with severe pneumonia admitted to General Hospital of the Northern War Zone were randomly divided into control group and observation group,with 50 cases in each group.The 2 groups were treated with general adjuvant therapy.The control group was treated with vancomycin on the basis of general supportive therapy.The observation group was treated with linezolid on the basis of general supportive therapy.The clinical effects,blood gas analysis indexes(SaO2,PaO2,Pa O2/Fi O2),serum inflammatory mediators(IL-6)and Interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)change,clinical symptoms disappearing time,adverse events were compared between the 2 groups.Results The effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05);after treatment,SaO2,PaO2 and PaO2/Fi O2 in the 2 groups were higher than those before treatment,and the difference was statistically significant(P<0.05);after treatment,the average IL-6,IL-8 and TNF-αwater in the 2 groups were lower than that before treatment,and the difference was statistically significant(P<0.05)The time of cough,fever,dyspnea and lung rale disappeared in the observation group was shorter than that in the control group(P<0.05);there was no significant difference in the incidence of adverse reactions between the 2 groups(P>0.05).Conclusion Using linezolid in the treatment of severe pneumonia can effectively improve the level of serum IL-6,IL-8,TNF-αand the situation of hypoxia in body,and shorten the time of clinical symptoms improvement.