喉咽清口服液联合常规用药治疗普通型新型冠状病毒肺炎的临床疗效及对免疫指标、炎症因子的影响

Clinical efficacy of the Houyanqing oral liquid plus conventional medication on immune indicators and infammatory factors in ordinary COVID-19

目的:观察喉咽清口服液联合常规用药治疗普通型新型冠状病毒肺炎(简称新冠肺炎)的临床疗效及对免疫指标、炎症因子的影响。方法:分别于张家界市人民医院和常德市第二人民医院收治26例普通型新冠肺炎患者,按治疗方法不同分为对照组和观察组,每组13例。对照组给予常规用药治疗,观察组在对照组用药的基础上加口服喉咽清口服液,每次10 m L,每天3次,两组均连续治疗2~3周。比较观察两组患者体温复常时间、核酸转阴时间、住院时间;治疗前及治疗满1周时分别进行发热、咳嗽、咽痛、咽干、乏力、胸闷症状评分,治疗前及治疗满2周时采用免疫荧光法测定血清降钙素,采用免疫投射比浊法测定血清C反应蛋白,采用酶联免疫吸附法检测免疫球蛋白M抗体和免疫球蛋白G抗体,治疗满2周时评估两组患者中医证候疗效及影像学疗效,记录不良反应发生情况。结果:观察组体温复常时间、核酸转阴时间、住院时间分别均明显短于对照组,均P<0.05。观察组治疗满1周时发热、咳嗽、咽痛、咽干、胸闷症状评分均明显低于本组患者治疗前的评分及对照组患者治疗后的评分,均P<0.05;乏力评分与对照组治疗后者差异无统计学意义,P>0.05。观察组治疗满2周时降钙素、C反应蛋白、免疫球蛋白M抗体、免疫球蛋白G抗体水平均明显低于治疗前及对照组治疗后(P<0.05)。观察组治疗满2周时的中医证候显效率明显高于对照组,差异有统计学意义,P<0.05;观察组治疗满2周时胸部CT影像正常率明显高于对照组,差异有统计学意义,P<0.05。结论:喉咽清口服液联合常规用药治疗普通型新冠肺炎具有确切效果,能够减轻炎症反应,有助于促进肺部炎症吸收,改善机体免疫功能,缩短核酸转阴时间,值得深入研究并推广应用。

Objective:To observe the clinical efficacy of the Houyanqing oral liquid(喉咽清口服液)with conventional medication on immune indicators and infammatory factors in ordinary COVID-19.Methods:Twenty-six cases were divided into the control group and observation group according to different treatment methods,with 13 cases in each group.The control group was given routine medication,and the observation group was given the Houyanqing oral liquid more,10 mL each time,and 3 times per day.Both groups were treated continuously for 2 to 3 weeks.Results:The time for body temperature to return to normal,the time for nucleic acid to turn negative,and the length of stay in the observation group were significantly shorter than those in the control group,all P<0.05.After 1 week of treatment,the symptom scores of fever,cough,sore throat,dry throat and chest tightness in the observation group were significantly lower than those in the group before treatment and those in the control group after treatment,all P<0.05.There was no significant difference in the latter treatment,P>0.05.After 2 weeks of treatment,the levels of calcitonin,C-reactive protein,immunoglobulin M antibody and immunoglobulin G antibody in the observation group were significantly lower than those before treatment and after treatment in the control group(P<0.05).The effective rate of TCM symptoms in the observation group after 2 weeks of treatment was significantly higher than the control group,P<0.05.The rate of chest CT images in the observation group after normal after 2 weeks of treatment was significantly higher than the control group,P<0.05.Conclusion:The Houyanqing oral liquid with routine medication has definite effect on ordinary COVID-19,can reduce the infammatory response,help to promote the absorption of lung infammation,improve the immune function of the body,and shorten the time for nucleic acid to turn negative,which is worthy of further study and promotion application.