气血并治方对动脉粥样硬化的疗效及ApoAⅠ、ApoB的变化研究

Study on Curative Effect and Changes of ApoAⅠand ApoB in Patients with Atherosclerosis Treated with Qixue Bingzhi Formula(气血并治方)

目的分析气血并治方对动脉粥样硬化患者的疗效及载脂蛋白AⅠ(ApoAⅠ)、载脂蛋白B(ApoB)的变化影响。方法选取医院2018年1月—2020年10月收治的动脉粥样硬化患者116例,根据治疗方法不同分为两组。对照组给予西药基础治疗,观察组在对照组基础上联合气血并治方治疗,分析两组患者治疗后的临床疗效。结果观察组总有效率为87.93%(51/58),对照组为65.52%(38/58),观察组患者总有效率高于对照组(P<0.05)。两组治疗前颈动脉内膜中膜厚度(IMT)、颈动脉血管阻力组间比较,差异不具有统计学意义(P>0.05)。观察组治疗后颈动脉IMT、颈动脉血管阻力低于对照组(P<0.05)。两组治疗前ApoAⅠ、ApoB、脂蛋白a(LPa)、人可溶性CD40配体(sCD40L)、超敏-C反应蛋白(hs-CRP)、白细胞介素-8(IL-8)水平组间比较,差异不具有统计学意义(P>0.05)。观察组治疗后ApoB、LPa、sCD40L、hs-CRP水平低于对照组,ApoAⅠ、IL-8水平与对照组组间比较,差异不具有统计学意义(P>0.05)。结论气血并治方治疗动脉粥样硬化疗效显著,可调节ApoB、LPa、sCD40L、hs-CRP的表达水平,抑制颈动脉内膜增厚,且安全性高。

Objective To analyze the effect of Qixue Bingzhi Formula(气血并治方)on atherosclerotic patients and the changes of apolipoprotein AⅠ(ApoAⅠ)and apolipoprotein B(ApoB).Methods A total of 116 of the patients with atherosclerosis were selected from January 2018 to October 2020 and were divided into two groups according to the treatment method.The control group received the basic treatment of western medicine,and the observation group combined Qixue Bingzhi Formula on the basis of the control group,and we analyzed the clinical curative effect after the treatment of the two patients.Results The total effective rate was 87.93%(51/58)in the observation group and 65.52%(38/58)in the control group,and the total effective rate in the observation group was higher than that in the control group(P<0.05).The intima-media thickness of carotid artery(IMT)and carotid artery resistance between the two groups were not statistically significant before treatment(P>0.05).Before treatment,ApoAⅠ,ApoB,lipoprotein a(LPa),human soluble CD40 ligand(sCD40L),hypersensitivity-C-reactive protein(hs-CRP)and leukocyte in the observation group were lower than those in the control group(P<0.05).The resistance of carotid artery and IMT in observation group after treatment were lower than those in the control group(P<0.05).The levels of IL-8 were not statistically significant(P>0.05).The levels of ApoB,LPa,sCD40L and hs-CRP in the observation group were lower than those in the control group.The levels of ApoB,LPa,sCD40L and hs-CRP were lower than those of the control group(P>0.05).Conclusion Qixue Bingzhi Formula is effective in the treatment of atherosclerosis and can regulate the levels of ApoB,LPa,sCD40L and hs-CRP,inhibit carotid intima thickening and has high safety.