针灸调节学习记忆损伤长时程增强机制的研究进展

Research Progress on Acupuncture and Moxibustion Regulating Long-Term Potentiation Mechanism of Learning and Memory Impairment

海马长时程增强(LTP)目前被认为是研究学习与记忆功能的经典细胞模型,多种学习记忆损伤性疾病都被证实与LTP障碍有关。针灸疗法传承千年,在治疗痴呆、中风等认知障碍疾病方面有着丰富的经验和可靠的疗效,研究显示,针灸改善学习记忆功能可能与修复突触可塑性,提高海马LTP密切相关,但针灸调节学习记忆损伤LTP的研究现状目前还少有报道,基于此,系统回顾和总结了相关文献,重点分析了针灸调节学习记忆损伤LTP涉及的疾病种类,调节方式和治疗效应,并探讨了针灸治疗方式和选穴的规律性,以期指导临床,并为后续研究提供参考。

The hippocampus long-term potentiation(LTP)is now considered classical cell model of research learning and memory function.A variety of learning and memory impaired diseases have been confirmed to LTP dysfunction.Acupuncture has a long history in the treatment of diseases such as dementia and stroke and has a wealth of experience and reliable curative effect.The research shows that the effect of acupuncture on learning and memory function may be closely related to repairing the synaptic plasticity and improving the hippocampal LTP.However,there are few reports on the regulation of LTP by acupuncture on impaired learning and memory.Based on this,the author summarized the related literature,and this paper focused on the analysis of the types of diseases involved in LTP in the regulation of learning and memory impairment by acupuncture and moxibustion,regulation modes and curative effects,and discussed the regularity of acupuncture treatment modes and acupoint selection,so as to guide the clinical practice and provide reference for subsequent studies.