黄芩苷防治动脉粥样硬化作用机制的研究进展

Research Progress on Prevention and Treatment of Atherosclerosis with Baicalin

中药黄芩属唇形科植物,性寒、味苦,具有清热燥湿、泻火解毒、止血安胎之功效。黄芩苷是从黄芩的根茎中提取并分离的主要黄酮类化合物,研究报道黄芩苷在动脉粥样硬化的治疗中显示出良好的疗效,其作用机制与减轻内皮细胞损伤、抑制巨噬细胞泡沫化、防止平滑肌细胞增殖与迁移、维持血小板与纤溶系统平衡、抑制树突状细胞成熟、调节T细胞免疫原性有关。通过查阅近年文献,整理并简要概述动脉粥样硬化的病理过程,拟围绕参与AS的主要细胞及其相关细胞因子系统综述黄芩苷治疗AS的临床研究和作用机制,为之后的临床应用和基础研究提供科学参考。

The traditional Chinese medicine Huangqin(Scutellaria baicalensis Georgi,SBG)is a plant in the Lamiaceae family.It is cold in nature and bitter in taste.It has the effects of clearing away heat and drying dampness,purging fire and relieving toxin,and stopping bleeding and preventing abortion.Baicalin is the main flavonoid compound extracted and isolated from the rhizomes of SBG.Studies have reported that baicalin has good curative effect in the treatment of atherosclerosis.Its mechanism of action is to reduce endothelial cell damage and inhibit macrophage foaming.It is related to preventing smooth muscle cell proliferation and migration,maintaining the balance of platelet and fibrinolytic system,inhibiting the maturation of dendritic cells,and regulating T cell immunogenicity.In the article,based on consulting the literature in recent years,sorting out and briefly summarizing the pathological process of atherosclerosis,it is planned to systematically review the clinical research and mechanism of baicalin in the treatment of atherosclerosis around the main cells involved in atherosclerosis and its related cytokines,which will provide scientific evidences for subsequent clinical applications and basic research.