麻杏石甘汤加味离子导入治疗小儿热性哮喘急性发作轻度50例临床观察

Clinical observation on 50 cases of children with asthma mild acute attack of heat type treated with Maxing Shigan Decoction modified ion introduction

目的观察麻杏石甘汤加味离子导入治疗小儿热性哮喘急性发作轻度的疗效。方法选取2016年1月至2017年4月就诊的热性哮喘急性发作轻度患儿150例,随机分为中药离子导入组(简称A组)、西药雾化吸入组(简称B组)、中药离子导入联合西药雾化吸入组(简称C组),各50例。治疗3 d后比较3组的哮喘症候积分改善情况,同时对中药离子导入治疗的患儿进行皮肤破损、过敏等情况的记录评估。结果C组总有效率为96.0%,显著高于A组的84.0%和B组的88.0%,差异均有统计学意义(P<0.05),A组和B组的总有效率比较,差异无统计学意义(P>0.05);3组治疗后喘息、咳嗽、哮鸣音及症候总积分与同组治疗前比较,差异均有统计学意义(P<0.01),且C组积分减少更显著,与A组和B组比较,差异均有统计学意义(P<0.05);采用中药离子导入治疗的100例患儿中,C组有1例治疗3 d后出现局部皮肤轻度发红、瘙痒,无破损,停用2 d后缓解。结论麻杏石甘汤加味离子导入联合西药雾化吸入治疗小儿热性哮喘急性发作轻度疗效满意且安全,简便易行,患儿依从性高,为中药离子导入治疗小儿哮喘的有效性提供了进一步的循证医学依据。

Objective To observe the effect of children with asthma mild acute attack of heat type treated with Maxing Shigan Decoction modified ion introduction.Methods 150 cases of children with asthma mild acute attack of heat type in our hospital from January 2016 to April 2017 were randomly divided into traditional Chinese medicine ion introduction group(referred to as group A),Western medicine atomization inhalation group(referred to as group B),traditional Chinese medicine ion introduction combined with Western medicine atomization inhalation group(abbreviated C group),each 50 cases.After 3 days of treatment,the asthmatic condition scores of the 3 groups were compared,and the skin lesions and allergies of the children treated with iontophoresis were evaluated.Results The total effective rate in the C group was 96.0%,which was significantly higher than that of the 84.0%in the A group and 88.0%in the B group,the difference was statistically significant(P<0.05),there was no significant difference in the total effective rate between group A and group B(P>0.05).The wheezing,cough,wheezing rale,and symptom scores after treatment in the 3 groups were statistically significant(P<0.01),and the scores in the C group decreased more significantly,compared with the A group and the B group,the differences were statistically significant(P<0.05).In the 100 cases of children treated with traditional Chinese medicine ion implantation,1 patient in C group had mild redness and itching after 3 days,no damage,and remission after 2 days.Conclusion Maxing Shigan Decoction modified ion introduction combine with Western medicine atomization inhalation treatment for children with asthma mild acute attack of heat type is satisfactory and safe,simple and easy to use,and highly complied by patients.It provides further evidence-based medical evidence for the effectiveness of TCM iontophoresis in the treatment of asthma in children.