杜仲叶环氧木脂素类化学成分研究

Chemical Constituents of Epoxy Lignans of Eucommia ulmoides Leaves

目的:研究杜仲叶中木脂素类化学成分。方法:采用各种柱色谱方法分离纯化,通过理化常数测定和光谱分析鉴定化合物的结构。结果:从杜仲叶中分离鉴定了12个环氧木脂素类化合物,分别为:(+)-新橄榄脂素(1)、8′-羟基-落叶松脂醇-4′-O-β-D-吡喃葡萄糖苷(2)、(-)-去氢二松柏醇-4-O-β-D-吡喃葡萄糖苷(3)、(-)-左旋马尾松树脂醇-3α-O-β-D-吡喃葡萄糖苷(4)、(8S,7′S,8′R)-vladinol D-4,4′-O-β-D-diglucopyranoside(5)、牛蒡子苷B(6)、(+)-8-羟基-松脂素-4′-O-β-D-吡喃葡萄糖苷(7)、(+)-8-羟基-松脂素-4,4′-O-β-D-双吡喃葡萄糖苷(8)、(+)-中脂素-4,4′-O-β-D-双吡喃葡萄糖苷(9)、prinsepiol-4-O-β-D-glucopyranoside(10)、连翘苷(11)、杜仲脂素A(12)。结论:化合物1~11为首次从该植物中分离得到。

Objective:To investigate the chemical components of epoxy lignans of Eucommia ulmoides leaves.Methods:The compounds were isolated and purified by various column chromatography methods,and the structures were identified by physical and chemical constants determination and spectral analysis.Results:Twelve epoxy lignans were isolated from Eucommia ulmoides leaves and identified as(+)-neoolivine(1),8′-hydroxyl-lariciresinol-4′-O-β-D-glucopyranoside(2),(-)-dehydrodiconiferylalcohol-4-O-β-D-glucopyranoside(3),(-)-massoniresinol-3α-O-β-D-glucopyranoside(4),(8S,7′S,8′R)-vladinol D-4,4′-O-β-D-diglucopyranoside(5),arctiinoside B(6),(+)-8-hydroxy-pinoresinol-4′-O-β-D-glucopyranoside(7),(+)-8-hydroxyl-pinoresinol-4,4′-O-β-D-diglucopyranoside(8),(+)-medioresinol-4,4′-O-β-D-diglucopyranoside(9),prinsepiol-4-O-β-D-glucopyranoside(10),forsythialanside E(11),eucommin A(12),respectively.Conclusion:Compounds 1 to 11 are isolated from Eucommia ulmoides for the first time.