木芙蓉花的化学成分研究

Chemical Constituents from the Flowers of Hibiscus mutabilis

目的:研究木芙蓉花的化学成分。方法:采用硅胶柱、MCI柱等多种层析技术对木芙蓉花90%乙醇提取物进行分离纯化,根据核磁数据等鉴定分离得到的化合物结构。结果:从木芙蓉花90%乙醇提取物中共分离纯化得到16个化合物,分别鉴定为:3,4-二羟基苯甲酸乙酯(1)、反式对羟基肉桂酸(2)、(S)-3-羟基-β-紫罗兰酮(3)、咖啡酸乙酯(4)、桂皮酸(5)、红花素(6)、反式对羟基肉桂酸乙酯(7)、原儿茶酸(8)、秦皮乙素(9)、咖啡酸(10)、东莨菪内酯(11)、5,5′-二甲基-[1,1′-联苯]-2,2′-二醇(12)、黑麦草内酯(13)、反式阿魏酸对羟基苯乙酯(14)、环烯酮A(15)、6-(4-hydroxy-3-methoxyphenyl)-5-(hydroxymethyl)-8-oxabicyclo[3.2.1]oct-3-en-2-one(16)。结论:其中,化合物2~4、6、12~16为首次从木槿属植物中分离得到。

Objective:To study the chemical constituents from the flowers of Hibiscus mutabilis.Methods:Various chromatographic techniques,including silica gel,MCI were used to isolate and purify the compounds from 90%ethanol extract of Hibiscus mutabilis flowers.Their structures were identified by NMR.Results:Sixteen compounds were isolated from 90%ethanol extract of Hibiscus mutabilis flowers and identified as ethyl 3,4-dihydroxybenzoate(1),E-p-hydroxy-cinnamic acid(2),(S)-3-hydroxy-β-ionone(3),ethyl caffeate(4),cinnamic acid(5),carthamidin(6),E-p-hydroxycinnamate(7),protocatechuic acid(8),aesculetin(9),caffeic acid(10),scopoletin(11),5,5′-dimethoxy-[1,1′-biphenyl]-2,2′-diol(12),loliolide(13),p-hydroxyphenethyl trans-ferulate(14),impecylone A(15),6-(4-hydroxy-3-methoxyphenyl)-5-(hydroxymethyl)-8-oxabicyclo[3.2.1]oct-3-en-2-one(16),respectively.Conclusion:Among them,compounds 2 to 4,6,12 to 16 are isolated from Hibiscus genus for the first time.