薏苡仁的化学成分研究

Chemical Constituents of Coix lacryma-jobi var.mayuen Kernel

目的:研究薏苡仁的化学成分。方法:利用硅胶柱色谱、ODS和HPLC等技术从薏苡仁甲醇提取物的正丁醇部位分离纯化其化学成分,并根据核磁共振波谱数据鉴定化合物的结构。结果:在薏苡仁中分离出17个化合物,分别鉴定为:腺苷(1)、肌苷(2)、2′-脱氧尿苷(3)、尿苷(4)、胸苷(5)、tatarine C(6)、zarzissine(7)、己内酰胺(8)、2-O-β-glucopyranosyl-7-methoxy-1,4(2H)-benzoxazin-3-one(9)、cinnamyl-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside(10)、rossicasin A(11)、(E)-caffeyl alcohol-4-O-β-glucopyranoside(12)、6′-O-feruloylsucrose(13)、benzyl-1-O-β-D-glucopyranosyl-(1→4)-β-D-glucopyranoside(14)、sibiricose A_(3)(15)、蔗糖(16)、邻苯二甲酸二丁酯(17)。结论:其中,化合物2~8、10~15、17为首次从该植物中分离得到。

Objective:To study the chemical constituents of Coix lacryma-jobi var.mayuen kernel.Methods:Silica gel column chromatography,ODS,HPLC and other methods were used to isolate and purify the chemical constituents from the n-butanol part of the methanol extract of Coix lacryma-jobi var.mayuen kernel,and the structures of the compounds were identified by the NMR data.Results:Seventeen compounds were isolated from Coix lacryma-jobi var.mayuen kernel and identified as adenosine(1),inosine(2),2′-deoxyuridine(3),uridine(4),thymidine(5),tatarine C(6),zarzissine(7),caprolactam(8),2-O-β-glucopyranosyl-7-methoxy-1,4(2 H)-benzoxazin-3-one(9),cinnamyl-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside(10),rossicasin A(11),(E)-caffeyl alcohol-4-O-β-glucopyranoside(12),6′-O-feruloylsucrose(13),benzyl-1-O-β-D-glucopyranosyl-(1→4)-β-D-glucopyranoside(14),sibiricose A_(3)(15),sucrose(16),dibutyl phthalate(17),respectively.Conclusion:Among them,compounds 2 to 8,10 to 15,17 are isolated from Coix lacryma-jobi var.mayuen for the first time.