南美蟛蜞菊花酚类化学成分研究

Chemical Constituents of Phenols from the Flowers of Sphagneticola trilobata

目的:研究南美蟛蜞菊花酚类化学成分。方法:综合运用硅胶柱层析、Sephadex LH-20葡聚糖凝胶、高效液相色谱等技术进行分离纯化,并运用NMR技术结合文献对这些化合物进行结构鉴定。结果:从南美蟛蜞菊花中分离得到15个酚类化合物,分别鉴定为:3′-羟基芫花素(1)、紫铆花素(2)、4,2′,4′-三羟基-3-甲氧基查尔酮(3)、甘草素(4)、7,3′,5′-三羟基二氢黄酮(5)、7,4′-二羟基-3′-甲氧基二氢黄酮(6)、7,3′,4′-三羟基-8-甲氧基二氢黄酮(7)、芫花素(8)、4′-甲氧基棉花素(9)、硫磺菊素(10)、异甘草素(11)、E-对羟基桂皮酸(12)、Z-对羟基桂皮酸(13)、Z-3-(2′,4′-二羟基苯基)-2-丙烯酸(14)、咖啡酸乙酯(15)。结论:除化合物3、6、8和12外,其余化合物均为首次从蟛蜞菊属植物中分离得到。除化合物8、12外,其余化合物均为首次从南美蟛蜞菊中分离得到。

Objective:To study the chemical constituents of phenols from the flowers of Sphagneticola trilobata.Methods:The compounds were isolated and purified by using silica gel,Sephadex LH-20,HPLC.Their structures were identified by NMR techonology and literature.Results:Fifteen phenols were isolated from the flowers of Sphagneticola trilobata and identified as 3′-hydroxygenkwanin(1),butein(2),4,2′,4′-trihydroxy-3-methoxycalcone(3),liquiritigenin(4),7,3′,5′-trihydroxyflavanone(5),7,4′-dihydroxy-3′-methoxyflavanone(6),7,3′,4′-trihydroxy-8-methoxyflavanone(7),genkwanin(8),4′-methyl gossypetin(9),sulphuretin(10),isoliquiritigenin(11),E-p-hydroxycinnamic acid(12),Z-p-hydroxycinnamic acid(13),Z-3-(2′,4′-dihydroxyphenyl)-2-propyl acid(14),caffeic acid ester(15),respectively.Results:Except for compounds 3,6,8,12,other compounds are isolated from Sphagneticola genus for the first time.Except for compounds 8 and 12,all the compounds are isolated from the Sphagneticola trilobata for the first time.