山茶花的化学成分研究

Chemical Constituents of Camellia japonica Flowers

目的:研究山茶花的化学成分。方法:综合运用多种分离纯化方法(硅胶、ODS、MCI、Sephadex LH-20凝胶等柱色谱和反相制备高效液相色谱等),结合理化性质和多种波谱学方法对分离得到的化合物进行结构鉴定。结果:从山茶花中共分离得到11个化合物,分别鉴定为:金丝桃苷(1)、山柰酚-3-O-洋槐糖苷(2)、山柰酚-3-O-[β-D-木糖(1→3)-α-L-鼠李糖(1→6)]-β-D-吡喃半乳糖苷(3)、8-甲氧基-山柰酚-3-O-葡萄糖苷(4)、山柰酚-3-O-β-D-芸香糖苷(5)、camellioside A(6)、camellioside C(7)、camellioside E(8)、山茶酮一醇(9)、齐墩果酸(10)、3β-羟基-齐墩果烷-11,13(18)-二烯-28酸(11)。结论:其中,化合物2和5为首次从该植物中分离得到,化合物3和4为首次从该属植物中分离得到。

Objective:To investigate the chemical constituents of Camellia japonica flowers.Methods:The compounds were isolated and purified by silica,ODS,MCI,Sephadex LH-20 column chromatographies and preparative HPLC.Their chemical structures were identified on the basis of physicochemical properties and various spectroscopic methods.Results:Eleven compounds were isolated from Camellia japonica flowers,and identified as hyperoside(1),kaempferol-3-O-robinobioside(2),kaempferol-3-O-[β-D-xylopyranosyl(1→3)-α-L-rhamnose(1→6)]-β-D-galactopyranoside(3),8-methoxy-kaempferol-3-O-glucoside(4),kaempferol-3-O-β-D-rutinoside(5),camellioside A(6),camellioside C(7),camellioside E(8),camellenodiol(9),oleanolic acid(10),3β-hydroxy-oleana-11,13(18)-dien-28-oic acid(11).Conclusion:Among them,compounds 2 and 5 are isolated from Camellia japonica for the first time.Compounds 3 and 4 are isolated from the genus for the first time.