Expression and clinical significance of CCL 18 in bronchoalveolar lavage fluid of connective tissue disease-associated interstitial lung disease

Objective To explore the expression and clinical significance of chemokine ligand 18(CCL18)in Bronchoalveolar Lavage Fluid(BALF)of patients with connective tissue disease-associated interstitial lung disease(CTD-ILD).Methods From January 2016 to June 2017,BALF of patients with rheumatoid arthritis-associated interstitial lung disease(RA-ILD group),patients with dermatomyositis-associated interstitial lung disease(DM-ILD group),and patients with primary Sj?gren syndrome-associated interstitial lung disease(pSS-ILD group)of Peking University People’s Hospital were collected.According to the prognosis of each group of patients during hospitalization,they were divided into the discharged and the died.Besides,30 patients without ILD served as a control group.Levels of CCL18 in BALF of all patients were tested by enzyme linked immunosorbent assay(ELISA).Cells in BALF of RA-ILD group,DM-ILD group and pSS-ILD group were collected and analyzed by absolute different cell counts.