Clinical value of myositis antibodies in patients with connective tissue disease-associated interstitial lung diseases

Objective To investigate the clinical significance of detection of myositis-specific antibodies(MSAs)and myositis-associated antibodies(MAAs)in patients with connective tissue disease-associated interstitial lung diseases(CTD-ILD).Methods Serum samples of 120 patients with CTD-ILD admitted to the Department of Respiratory,Affiliated Drum Tower Hospital of Nanjing University Medical College from December 2016 to April 2018 were collected for analysis.The patients included 45 with polymyositis/dermatomyositis(PM/DM),36 with Sjogren s syndrome(SS)and 39 with undifferentiated connective tissue disease(UCTD).There were 37 males and 83 females with an average age of(56±11)years.Thirty-two patients with non-CTD-ILD,10 males and 22 females with an average age of(42±17)years,were enrolled as the control group.Euroline Autoimmune Inflammatory Myopathies 16 Ag kit was used for detecting MSAs and MAAs,and the positive rates of serum MSAs and MAAs were calculated.