MIF、sICAM-1、visfatin及AFP在PHC患者血清中的表达及与患者病情判断及肝纤维化的关系研究

Expression of MIF,sICAM-1,visfatin and AFP in serum of patients with PHC and its relationship with disease judgment and liver fibrosis

[目的]探讨巨噬细胞移动抑制因子(MIF)、可溶性细胞间黏附分子-1(sICAM-1)、内脂素(visfatin)、甲胎蛋白(AFP)在原发性肝癌(PHC)中的表达,及与患者病情判断和肝纤维化的关系。[方法]选取2015年1月~2018年12月收治的50例PHC患者为PHC组,50例肝脏良性病变患者为对照组;检测患者血清中MIF、sICAM-1、visfatin、AFP水平,绘制ROC曲线分析各指标单独诊断及联合诊断的价值;对PHC患者的肝纤维化程度进行评估,分析MIF、sICAM-1、visfatin、AFP水平与患者肝纤维化的关系。[结果]PHC组MIF、sICAM-1、visfatin、AFP水平均高于对照组(P<0.05);MIF、sICAM-1、visfatin、AFP联合诊断的敏感度、特异度及AUC均明显高于各指标单独应用(P<0.05);PHC患者0~2级纤维化MIF、sICAM-1、visfatin、AFP水平明显低于3~4级(P<0.05);MIF、sICAM-1、visfatin、AFP是影响PHC患者肝纤维化发展的独立性危险因素(P<0.05)。[结论]PHC患者血中MIF、sICAM-1、visfatin水平显著高于肝脏良性病变组,MIF、sICAM-1、visfatin、AFP联合诊断可有效提高PHC的诊断价值,此外MIF、sICAM-1、visfatin、AFP是影响PHC肝纤维化的独立性危险因素。

[Objective]To analyze the relationship between migration inhibitory factor(MIF),soluble intercellular adhesion molecule-1(sICAM-1),visfatin in primary hepatic cancer(PHC),AFP(Alpha-fetoprotein)and patient’s condition and liver fibrosis.[Methods]One hundred patients with PHC admitted from January 2017 to December 2018 were enrolled in the study.100 patients with benign liver lesions were used as control group.The levels of MIF,sICAM-1,visfatin and AFP in serum were measured and ROC was drawn.Curve analysis of each index for the diagnosis and combined diagnostic value;assessment of the degree of liver fibrosis in patients with PHC,analysis of the relationship between MIF,sICAM-1,visfatin and AFP levels and liver fibrosis.[Results]The levels of MIF,sICAM-1,visfatin and AFP in the blood of patients with PHC were higher than those of the control group,and the difference was statistically significant(P<0.05).The sensitivity,specificity and AUC of MIF,sICAM-1,visfatin and AFP were significantly different.Higher than the individual indicators,and the difference was statistically significant(P<0.05);PHC patients with grade 0—2 fibrosis MIF,sICAM-1,visfatin and AFP levels were significantly lower than grade 3—4,and the difference was statistically significant(P<0.05);MIF,sICAM-1,visfatin and AFP were independent risk factors for the development of liver fibrosis in patients with PHC(P<0.05).[Conclusion]The levels of MIF,sICAM-1,visfatin and AFP in the blood of patients with PHC were significantly higher than those in the benign liver lesions,and the combined diagnosis of MIF,sICAM-1,visfatin and AFP could effectively improve the diagnostic value of PHC.In addition,MIF,sICAM-1,visfatin and AFP belong to the liver fiber of PHC.Independence risk factors.