季节对皮肤斑贴试验阳性结果的影响

Seasonal influences on positive results of skin patch tests

目的探究不同季节因素对皮肤斑贴试验中硫酸镍"++"/"+++"阳性结果的影响。方法按就诊的先后顺序,选取苏州地区66例皮肤斑贴试验中硫酸镍阳性结果"++"/"+++"的门诊患者。在冬季行第1次斑贴试验,夏季再行第2次斑贴试验。测试严格按照国际接触性皮炎研究组(ICDRG)的指南进行统一操作。将测试中相关变应原的反应程度按"-","±"、"+"、"++"、"+++"进行相关分析。结果65名完成测试的受试者中,冬季21例为"++"、45例为"+++";夏季18例为"++"、47例为"+++"。两次斑贴试验结果差异无统计学意义(Z=-1.000,P=0.317)。结论季节因素对皮肤斑贴试验中硫酸镍阳性结果"++"/"+++"无明显影响。

Objective To explore the influences of different seasons on positive++/+++skin patch test results of nickel sulfates.Methods Sixty six patients with positive(++/+++)patch test reactions to nickel sulfates were sequentially collected at the dermatology outpatient clinic.The first and second patch tests were conducted in the the winter and summer respectively.The patch tests were strictly conducted according to the guidelines of International Contact Dermatitis Research Group(ICDRG).The reaction degrees of allergens in patch tests were subject to correlation analysis in terms of"-","±","+","++"and"+++".Results Sixty-five testers completed the study,the results in winter were 21 cases with++and 45 cases with+++,and the summer results were 18 cases with++,47 cases with+++.No statistical significance was found with the difference between two patch tests(Z=-1.000,P=0.317).Conclusion No significant effect of Seasonal influences are found on positive results"++/+++"of nickel sulfates in skin patch tests.