血清IL-34水平评估非病毒性肝细胞癌患者预后的临床价值

The clinical values of serum interleukin-34 levels in evaluating the prognosis of patients with non-viral hepatocellular carcinoma

目的评估血清IL-34预测非病毒性肝细胞癌患者(HCC)预后的临床价值。方法选择2013年3月至2014年3月我院收治的100例非病毒性肝细胞癌患者(非病毒性HCC组)和100例健康体检者(对照组)。通过ELISA评估血清IL-34水平。结果非病毒性HCC组血清IL-34水平[(15.89±6.21)pg/mL]显著高于对照组[(3.03±0.83)pg/mL,t=22.122,P<0.001]。PLT、ALT、AST、ALP、总胆红素、AFP、Child-pugh分级、肿瘤大小、肿瘤分期与IL-34呈正相关。ROC分析血清IL-34对非病毒性HCC的AUC=0.889,截断值8.87 pg/mL,P<0.001,95%CI 0.820~0.958,敏感性82.98%,特异性92.45%。高IL-34(≥8.87 pg/mL,n=41)和低IL-34(<8.87 pg/mL,n=59)生存率具有统计学差异(χ2=14.360,P=0.002)。Cox比例风险模型分析AFP、肿瘤大小、肿瘤分期、IL-34是非病毒性HCC预后危险因素。结论IL-34是非病毒性肝细胞癌患者生存预后的独立因素,IL-34可能与非病毒性肝细胞癌预后有关。

Objective To evaluate the clinical value of serum interleukin-34(IL-34)levels in evaluating the prognosis of patients with non-viral hepatocellular carcinoma patients(HCC).Methods One hundred patients with non-viral HCC(non-viral HCC group)and 100 healthy subjects(control group)in our hospital from March 2013 to March 2014 were enrolled.Serum IL-34 levels were assessed by ELISA.Results Serum IL-34 levels in the non-viral HCC group[(15.89±6.21)pg/mL]were significantly higher than those in the control group[(3.03±0.83)pg/mL,t=22.122,P<0.001].Platelet(PLT),alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),total bilirubin,alpha fetoprotein(AFP),Child-Pugh Score,tumor size,tumor stage were positively correlated with serum IL-34 levels.The area under the receiver operating characteristics curve of serum IL-34 levels for discriminating patients with nonviral HCC was 0.889(P<0.001,95%CI 0.820-0.958,sensitivity 82.98%,specificity 92.45%),with the cut-off value of 8.87 pg/mL.The survival rates of high IL-34(>8.87 pg/mL,n=41)and low IL-34(<8.87 pg/mL,n=59)were statistically different(χ2=14.360,P=0.002).AFP,tumor size,tumor stage and serum IL-34 level were independent prognostic risk factors for non-viral HCC by Cox proportional hazard model.Conclusion Serum IL-34 level is an independent prognostic factor for non-viral HCC,which may be associated with the prognosis of non-viral HCC.