三维适形放疗联合TACE治疗中晚期肝癌患者的早期疗效

Early effect of three-dimensional conformal radiotherapy on liver cancer patients received transcatheter arterial chemoembolization therapy

目的探究三维适形放疗联合经导管动脉栓塞化疗(TACE)对中晚期肝癌患者的早期临床疗效。方法回顾性选择2015年7月至2018年7月我院收治的原发性肝癌患者,按照接受的治疗方法不同分为联合组(n=56)与单纯TACE组(n=68)。联合组接受TACE与三维适形放疗联合治疗,单纯TACE组仅接受TACE治疗。观察两组治疗后早期临床疗效、毒副反应,随访1年后两组存活情况。结果联合组早期治疗有效率为73.21%(41/56)高于单纯TACE组早期有效率52.94%(36/68)(P<0.05)。联合组中放疗期间总放疗毒副反应发生率为33.93%(19/56),其中发生急性放射性胃炎、急性放射性肝损伤、白细胞计数低于2.5×109/L的患者各1例,占比1.79%(1/56),两组治疗1年后总存活率比较无显著差异(P>0.05)。结论对于中晚期肝癌患者,在TACE基础上增加三维适形放疗治疗能明显提高早期临床疗效,无严重放疗不良反应,具有良好安全性。

Objective To investigate the early effect of three-dimensional conformal radiotherapy on liver cancer patients with transcatheter arterial chemoembolization(TACE).Methods One hundred and twenty-four patients with advanced primary liver cancer were retrospectively selected in this study,They were divided into combined group(n=56)and simple TACE group(n=68)according to the treatment they had received.The early clinical efficacy,adverse reactions,and survival rate were observed in 1-year’s follow-up period of time.Results The early effective rate of the combined group was higher than that of the TACE group(73.21%vs 52.94%,P<0.05).The incidence of total toxicity and side effects during radiotherapy in the combined group was 33.93%,including 1 case(1.79%)of acute radiation gastritis,1 case(1.79%)of acute radiation liver injury,1 case(1.79%)of leucocytes count lower than 2.5×109/L.There was no significant difference in overall survival rate between the two groups at 1 year after the treatment(P>0.05).Conclusion For patients with advanced liver cancer,TACE combined with three-dimensional conformal radiotherapy can effectively improve the early clinical efficacy,without severe radiotherapy toxicity and side effects.