摘要
正电子发射断层成像(Positron Emission Tomography,PET)能直接观测活体内的生理生化过程,具有高特异性和高生化灵敏度。2004年,多电压阈值(Multiple Voltage Threshold,MVT)采样方法被提出,解决了PET系统中高速闪烁脉冲精确数字化难题,使得全数字PET的研制成为可能。数字PET技术以MVT为源头向着PET创新链的上下游环节延展,为关键材料、核心器件、智能算法和应用研究带来了新的机遇。本文回顾了数字PET诞生和发展的历程,并展望了基于数字PET平台创新可能产生的问题与机遇,以供相关研究者探讨。
Positron Emission Tomography(PET)can directly depict biological processes and physiological functions,with excellent specificity and exceptional biochemical sensitivity.The Multiple Voltage Threshold(MVT)approach proposed in 2004 has paved the way for the invention of digital PET technology,by realizing accurate digitization of high-speed scintillation pulses in PET systems.Originated from the MVT sampling methods,the innovation of digital PET technology has been expanded along the PET innovation chain,changing the research landscapes of fundamental materials,key devices,sophisticated algorithms,and biomedicine applications.This article provided a comprehensive review of the development of digital PET,covering the MVT method,detectors,and systems.It also discussed the challenges and opportunities that might be faced by future researchers who are interested in exploring the innovation architecture based on the digital PET technology.
作者
邱奥
张博
肖鹏
谢庆国
QIU Ao;ZHANG Bo;XIAO Peng;XIE Qingguo(Department of Biomedical Engineering,Huazhong University of Science and Technology,Wuhan 430074,China;Raysolution Technology Co.,Ltd.(Hefei),Hefei 230093,China;Wuhan National Laboratory for Optoelectronic,Wuhan 430074,China;Department of Electronic Engineering and Information Science,University of Science and Technology,Hefei 230052,China)
出处
《中国体视学与图像分析》
2022年第4期323-333,共11页
Chinese Journal of Stereology and Image Analysis
基金
国家自然科学基金(No.61927801,62250002)
