抗CD74抗体在不同病程的中轴型脊柱关节炎患者中的水平变化及与疾病活动度的关系

Changes of anti-CD74 antibodies in axial spondyloarthritis patients with different disease duration and its relationship to disease activity

目的探讨抗CD74抗体在不同病程的中轴型脊柱关节炎(axSpA)患者中的水平变化,以及与疾病活动度之间的关系。方法选取114例axSpA患者,包括100例强直性脊柱炎(AS)患者,14例放射学阴性中轴型脊柱关节炎(nr-axSpA)患者为研究对象,20例外周型脊柱关节炎患者(pSpA)、47例健康人(HC)为对照组。收集临床资料,用BASDAI、ASDAS评估疾病活动度。通过ELISA试剂盒检测各组血清中的抗CD74抗体IgG型浓度。结果axSpA(AS组、nr-axSpA组)患者的抗CD74抗体浓度与对照组相比差异无统计学意义(P>0.05)。但AS组、nr-axSpA组的抗CD74抗体IgG型浓度的平均值均高于pSpA组和HC组。axSpA患者根据病程分组,axSpA患者病程<3年的抗CD74抗体IgG型浓度明显高于病程3~10年和>10年(P=0.001,P<0.001)。根据BASDAI、ASDAS将axSpA患者分组,不同疾病活动度的抗CD74抗体浓度差异无统计学意义(P>0.05)。axSpA患者按照病程和BASDAI分组,在病程<3年、3~10年及>10年的患者中,BASDAI≥4组(疾病活动期)与BASDAI<4组(疾病缓解期)患者的抗CD74抗体浓度差异均无统计学意义(P>0.05)。结论与长病程相比,病程短(<3年)的axSpA患者的抗CD74抗体的浓度更高。抗CD74抗体的浓度与疾病活动度之间无相关性。

Objective To investigate the changes of anti-CD74 antibodies in axial spondyloarthritis patients with different disease duration and its relationship to disease activity.Methods A total of 114 axSpA patients(including 100 AS patients and 14 nr-axSpA patients)were selected as the study subjects,20 patients with peripheral spinal arthritis(pSpA)and 47healthy control(HC)subjects were selected as the control group.Clinical data were collected.BASDAI and ASDAS were measured as markers of disease activity.ELISA kit was performed to detect the concentration of anti-CD74 IgG antibodies in serum of each group.Results There was no significant difference in the concentration of anti-CD74 antibodies between axSpA group(AS patients and nr-axSpA patients)and the control group(P>0.05).However,the mean concentration of anti-CD74 antibodies in AS group and nr-axSpA group was higher than that in pSpA group and HC group.Patients with axSpA were grouped according to disease duration.The concentration of anti-CD74 IgG antibodies was significantly higher in patients with disease duration<3years than in patients with disease duration 3~10years and>10years(P=0.001,P<0.001).The axSpA patients were grouped according to BASDAI and ASDAS,and there was no statistical difference in the concentration of anti-CD74antibodies in different disease activity levels(P>0.05).Thereafter,axSpA patients were grouped according to disease duration and BASDAI.There was no significant difference in anti-CD74 antibodies concentration between BASDAI≥4 and<4groups in patients with disease duration<3years,3~10years and>10years(P>0.05).Conclusion Compared to axSpA patients with long disease duration,patients with short disease duration(<3years)had higher concentrations of anti-CD74 antibodies.There was no correlation between the concentration of anti-CD74 antibodies and disease activity.