老年体检人群血脂异常检出情况及其与冠心病发病的关联性分析

Detection of blood lipid abnormalities in elderly physical examination population and its correlation with the incidence of coronary heart disease

目的观察老年体检人群血脂异常检出情况,并分析其与冠心病(CHD)发病的关联性。方法选取四川大学华西医院154例老年体检者,根据是否发生CHD,分为CHD组与非CHD组,收集其临床资料,分析血脂[甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]检测结果及CHD影响因素。结果154例受检者中,92例(59.74%)血脂异常,包括低HDL-C 39例(25.32%),高TC 20例(12.99%),高LDL-C 17例(11.04%),高TG 16例(10.39%);男性低HDL-C检出率明显高于女性(P<0.05),女性高TC、高TG及高LDL-C检出率明显高于男性(P<0.05);血脂异常检出率为:60~69岁者>70~79岁者>80岁及以上者(P<0.05);CHD组与非CHD组吸烟史、饮酒史及血脂异常率比较有统计学意义(P<0.05);Logistic回归分析发现,吸烟史、饮酒史及血脂异常属于老年人CHD发病主要危险因素(P<0.05)。结论老年体检人群血脂异常检出率高,尤其是60~69岁老年人,血脂异常可增加冠心病发病风险。

Objective To observe the detection of blood lipid abnormalities in elderly physical examination population,and analyze its relationship with coronary heart disease(CHD).Methods A total of 154 elderly individuals who received physical examination in the hospital were selected,and divided into CHD group and non-CHD group according to presence or absence of CHD.Their clinical data were collected.The test results of blood lipids[triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)]and influencing factors of CHD were analyzed.Results Of 154 subjects,92(59.74%)had abnormal blood lipids,including 39(25.32%)with low HDL-C,20(12.99%)with high TC,17(11.04%)with high LDL-C,and 16(10.39%)with high TG.The detection rate of low HDL-C in males was significantly higher than that in females(P<0.05),and the detection rates of high TC,high TG and high LDL-C in females were significantly higher than those in males(P<0.05).The detection rate of blood lipid abnormalities decreased in order from the 60~69 year-old group,the 70~79 year-old group to the>80 year-old group(P<0.05).There were statistically significant differences in smoking history,drinking history,and incidence of blood lipid abnormalities between the CHD group and the non-CHD group(P<0.05).Logistic regression analysis found that smoking history,drinking history and abnormal blood lipids were main risk factors for CHD in the elderly(P<0.05).Conclusion The detection rate of blood lipid abnormalities in elderly physical examination population is high,especially in the elderly aged 60~69.Blood lipid abnormalities can increase the risk of CHD.