基于系统文献检索的桔青霉素遗传毒性分析与识别

Genotoxicity analysis and identification of citrinin based on a systematic literature search

桔青霉素是由曲霉属、青霉属和红曲霉属等真菌产生的聚酮类真菌毒素,常污染谷物及其制品。桔青霉素具有明确的肾脏毒性,但其致癌性证据有限。考虑到遗传毒性试验可用于筛查化学物质潜在致癌性,本文从基因突变、染色体畸变和DNA损伤3个遗传学终点的角度对桔青霉素的遗传毒性进行综述。桔青霉素是一种致染色体畸变的遗传毒性物质,机制可能与其影响细胞有丝分裂期间微管蛋白聚合与纺锤体形成,导致细胞周期阻滞有关。本文期望为桔青霉素风险评估工作提供基础数据结论。

Citrinin(CIT)is a mycotoxin produced by several species of the genera Aspergillus,Penicillium,and Monascus,and it often contaminates grains and grain products.CIT shows clear nephrotoxicity,while its carcinogenicity evidence is insufficient.Considering the ability of genotoxicity tests to screen chemicals for potential carcinogenicity,the genotoxicity of CIT was reviewed from the perspective of three genetic endpoints,including genetic mutation,chromosomal aberrations,and DNA damage.CIT is a genotoxic substance that induces chromosomal aberrations.The mechanism may be related to its influence on tubulin polymerization and spindle formation during cellular mitosis,thereby causing cell cycle blocking.This study provides basic data for follow-up risk assessments of CIT.