中医药治疗脾虚湿阻型单纯性肥胖症的临床观察

Clinical Observation on the Treatment of Simple Obesity of Spleen Deficiency and Dampness Resistance Type with Traditional Chinese Medicine

目的:探究中医药治疗脾虚湿阻型单纯性肥胖症的临床效果。方法:选取2022年1月—2023年6月本院接诊的100例脾虚湿阻型单纯性肥胖症患者,按随机数表法分为对照组与研究组,各50例。两组均行基础治疗,在此基础上对照组接受空白颗粒剂治疗,研究组接受芪黄颗粒剂治疗。观察两组疗效,并于治疗前及治疗8周后对两组中医证候积分、体质量、身体质量指数(BMI)、腰臀比(WHR)、血脂[高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、总胆固醇(TC)]及瘦素、脂联素进行对比。结果:研究组治疗总有效率(93.33%,42/45)高于对照组(76.60%,36/47)(P<0.05)。两组治疗后肢体困重、疲乏无力积分比治疗前低,且研究组比对照组低(P<0.05)。两组治疗后体质量、BMI比治疗前低,且研究组比对照组低(P<0.05);两组治疗后WHR对比差异无统计学意义(P>0.05)。两组治疗后HDL-C比治疗前高,LDL-C、TG、TC比治疗前低,且研究组优于对照组(P<0.05)。两组治疗后瘦素比治疗前低,脂联素比治疗前高,且研究组优于对照组(P<0.05)。结论:芪黄颗粒剂治疗脾虚湿阻型单纯性肥胖症的临床效果确切,可明显改善肥胖指标,调节机体血脂及瘦素、脂联素水平。

Objective:To explore the clinical effect of traditional Chinese medicine in treating simple obesity of spleen deficiency dampness obstruction type.Method:100 patients with simple obesity of spleen deficiency dampness obstruction type who were treated in our hospital from January 2022 to June 2023 were selected and randomly divided into a control group and a study group with 50 cases each.Both groups received basic treatment,with the control group receiving blank granules and the research group receiving Qihuang granules.Observe the curative effect of the two groups,and compare the TCM syndrome score,body weight,body mass index(BMI),waist hip ratio(WHR),blood lipids[high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),triglycerides(TG),total cholesterol(TC)],leptin and adiponectin before and after 8 weeks of treatment of the two groups.The therapeutic effect of the study group was 93.33%(42/45),which was higher than 76.60%(36/47)of the control group(P<0.05).After treatment,the scores of limb fatigue and weakness in both groups were lower than before treatment,and the study group was lower than the control group(P<0.05).After treatment,the body weight and BMI of the two groups were lower than before treatment,and the study group was lower than the control group(P<0.05);There was no difference in WHR between the two groups after treatment(P>0.05).After treatment,HDL-C was higher in both groups compared to before treatment,while LDL-C,TG,and TC were lower than before treatment,and the study group was better than the control group(P<0.05).After treatment,both groups had lower levels of leptin and higher levels of adiponectin compared to before treatment,and the study group was better than the control group(P<0.05).Conclusion:Qihuang granules have a definite clinical effect on treating simple obesity of spleen deficiency dampness obstruction type,which can significantly improve the obesity indicators of patients,regulate the body's blood lipids and levels of leptin and adiponectin.