类风湿性关节炎维吾尔医证型与临床检验指标的相关性研究

Study on the correlation between Uyghur medical syndrome types and clinical test indicators in rheumatoid arthritis

目的:探讨类风湿性关节炎维吾尔医证型的分布与临床检验指标的相关性。方法:选择2018年2月—2022年6月于新疆维吾尔自治区维吾尔医医院(新疆维吾尔自治区第二人民医院)住院的类风湿性关节炎患者,根据维吾尔医辨证分型标准,分为无味黏液质型、石膏状黏液质型、涩味黏液质型、异常脾液质型,观察类风湿性关节炎维吾尔医证型分布及与临床指标关系。结果:类风湿性关节炎患者的常见证型为涩味黏液质证;女性(77.4%)多于男性(22.6%)。经χ2检验得出,维吾尔医证型分布与性别的差异无统计学意义。经单因素方差分析或非参数检验分析发现,4个证型中HB、GLU、RF、CRP指标差异有统计学意义(P<0.05)。两两比较,石膏状黏液质型中HB对比其他证型组显著降低(P<0.05),石膏状黏液质型中RF、CRP对比其他证型显著升高(P<0.05),异常脾液质型中GLU对比其他证型显著降低(P<0.05),其他证型两两比较差异无统计学意义。按照前面单因素分析中有显著差异指标筛选后,得到HB、RF、CRP、GLU进一步ROC曲线分析,结果显示HB、RF、CRP、GLU诊断维吾尔医4种证型类风湿性关节炎的曲线面积分别为0.354,0.666,0.693,0.615。结论:类风湿性关节炎维吾尔医证型与临床相关指标有一定相关性,且RF、CRP、GLU对维吾尔医类风湿性关节炎有一定诊断价值,维吾尔医辨证提供比较客观的依据。

Objective:To study the correlation between the distribution of medical syndrome types of rheumatoid arthritis in Uygur and clinical test indexes.Methods:The patients with rheumatoid arthritis who were hospitalized in the Xinjiang Uygur Medical Hospital(the Second People's Hospital of Xinjiang Uygur Autonomous Region)from February 2018 to June 2022 were selected.According to the standard of Uygur medical syndrome differentiation,they were divided into five syndrome types:Odorless Hilt,odorless Hilt,Gypsum Hilt,Astringent Hilt,and Abnormal Splenic Hilt.The distribution of Uygur medical syndrome types of rheumatoid arthritis and the relationship between them and relevant clinical indicators were observed.Result:Astringent hilt was more common in female(77.4%)than male(22.6%)patients with rheumatoid arthritis.Throughχ2 test concluded that there was no statistical significance between the distribution of medical syndrome type of Uyghur and gender.Significant differences(P<0.05)in Hb,Glu,RF and CRP indexes among the four syndromes were found by one-way ANOVA or non-parametric test analysis.In pairwise comparisons,Hb in plaster mucinous type was significantly lower than other syndrome groups(P<0.05),RF and CRP in plaster mucinous type were significantly higher than other syndrome groups(P<0.05),Glu in abnormal spleen mucinous type was significantly lower than other syndrome groups(P<0.05),and there was no significant difference between two comparisons in other syndrome types.After screening according to the indicators with significant differences in the previous univariate analysis,further ROC curve analysis was performed to obtain Hb,RF,CRP,Glu,and the results showed that the curve areas of Hb,RF,CRP,and Glu for the diagnosis of four syndromic RA were 0.354,0.666,0.693,and 0.615,respectively.Conclusion:There was a correlation between the medical syndrome type of Uyghur and clinically relevant indicators,and RF,CRP,Glu had a certain diagnostic value of Uyghur medical rheumatoid arthritis,and Uyghur medical syndrome differentiation provided a comparative objective basis.