银屑病中免疫抑制性细胞及中医药对其调控作用的研究进展

Research advancements of immunosuppressive cells and its regulation by traditional Chinese medicine in psoriasis

银屑病是一种常见的难治性皮肤病,以过度激活的T细胞产生的异常免疫应答为主要特征。在机体免疫系统内,免疫抑制性细胞主要包括髓源抑制细胞(MDSCs)、调节性T细胞(Tregs)、调节性B细胞(Bregs)、巨噬细胞(Mφ)等,它们可以预防T细胞等免疫效应细胞的异常活化和增殖,维持免疫稳态。近年来随着对银屑病研究的深入,发现银屑病中的免疫抑制性细胞存在异常表现,可能影响银屑病的发生发展,但根据文献检索发现,国内医学尤其是中医药对银屑病中免疫抑制性细胞的探讨明显匮乏,故本文以此为切入点,探讨银屑病中免疫抑制性细胞的募集和功能变化以及中医药对此类细胞的调控作用,旨在更深入和全面地了解银屑病的发病机制,为临床上延缓银屑病进程提供新的策略。

Psoriasis is a common refractory skin disease and characterized by abnormal immune responses produced by overactivated T cells.In the body’s immune system,myeloid-derived suppressor cells(MDSCs),regulatory T cells(Tregs),regulatory B cells(Bregs),macrophages(Mφ),etc.are included in immunosuppressive cells,and they prevent abnormal activation and proliferation of immune effector cells such as T cells to maintain immune homeostasis.In recent years,with in-depth research on psoriasis,it has been found that there are abnormal expressions of immunosuppressive cells in psoriasis,which may affect the occurrence and development of psoriasis.However,according to literature search,it is found that the research on immunosuppressive cells in psoriasis is obviously lacking in domestic medicine,especially Chinese medicine.Therefore,our article on the basis of this starting point to explore the recruitment and functional changes of immunosuppressive cells in psoriasis and the regulatory effects of traditional Chinese medicine on them,aims at a deeper and comprehensive understanding of the pathogenesis of psoriasis and provides new potential strategies for clinical medicine to delay the progression of psoriasis.