肿瘤标志物和凝血功能联合检测在结直肠癌的诊断价值和相关性研究

DIAGNOSTIC VALUE AND CORRELATION STUDY ON COMBINED DETECTION OF TUMOR MARKERS AND COAGULATION FUNCTION IN COLORECTAL CARCINOMA

目的探讨肿瘤标志物和凝血功能联合检测在结直肠癌中的诊断价值及关联性。方法选取2017年1月—2019年12月于华北理工大学附属医院住院治疗的结直肠癌患者94例作为肿瘤组,选取同期住院的结直肠良性疾病患者128例作为非肿瘤组。观察二组患者的凝血功能和肿瘤标志物指标,分析在结直肠癌中的变化及相关性。结果肿瘤组纤维蛋白原(FIB)、癌胚抗原(CEA)、糖类抗原19-9(CA19-9)高于非肿瘤组,凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)低于非肿瘤组,差异有统计学意义(P<0.05);TNM分期中,Ⅲ+Ⅳ期患者FIB、CEA、CA19-9高于Ⅰ+Ⅱ期患者,差异有统计学意义(P<0.05)。转移组患者FIB、CEA、CA19-9高于无转移组患者,差异有统计学意义(P<0.05)。FIB、CEA、CA19-9联合检测的灵敏度、特异度、准确度均高于FIB(χ^(2)=25.532、32.880、18.523,P=0.000、0.000、0.000)、CEA(χ^(2)=12.511、12.587、21.023,P=0.000、0.000、0.000)、CA19-9(χ^(2)=16.817、8.308、9.820,P=0.000、0.004、0.002)单项检测,差异有统计学意义(P<0.05)。结论肿瘤标志物和凝血功能检测对诊断结直肠癌及监测血栓的形成和肿瘤进展有一定价值,采用FIB、CEA、CA19-9联合检测诊断价值较高,明显提高准确率、灵敏度及特异度,有利于早期防治。

Objective To explore the diagnostic value and correlation research of combined detection of tumor markers and coagulation function in colorectal carcinoma.Methods Ninety four patients with colorectal carcinoma hospitalized in the Affiliated Hospital of North China University of Science and Technology from January 2017 to December 2019 were selected as the tumor group,and 128 patients with benign colorectal diseases hospitalized during the same period were selected as the non-tumor group.Retrospective analysis of the coagulation function and tumor markers of the two groups of patients,analysis of changes and correlation in colorectal carcninoma.Results Fibrinogen(FIB),carcinoembryonic antigen(CEA),carbohydrate antigen 19-9(CA19-9)in tumor group were higher than those in non-tumor group,prothrombin time(PT),activated partial prothrombin time(APTT)lower than non-tumor group,the difference was statistically significant(P<0.05);in TNM stage,FIB,CEA,CA19-9 in stageⅢ+Ⅳpatients were higher than those in stageⅠ+Ⅱ,the difference was statistically significant(P<0.05).The FIB,CEA,CA19-9 in the metastatic group were higher than those in the non-metastatic group,and the difference was statistically significant(P<0.05).The sensitivity,specificity,and accuracy of the combined detection of FIB,CEA,and CA19-9 are higher than FIB(χ^(2)=25.532,32.880,18.523,P=0.000,0.000,0.000),CEA(χ^(2)=12.511,12.587,21.023,P=0.000,0.000,0.000),CA19-9(χ^(2)=16.817,8.308,9.820,P=0.000,0.004,0.002),the difference was statistically significant(P<0.05).Conclusion The detection of tumor markers and blood coagulation function can help to identify benign and colorectal benign and carcinoma and to monitor the formation of thrombosis.The combined detection of FIB,CEA and CA19-9 is of high diagnostic value,which significantly improves accuracy,sensitivity and specificity Conducive to early prevention.