认知正常老年人海马亚区体积的性别差异

Sex differences of hippocampal subfield volumes in cognitively normal elderly

目的探讨认知正常老年人海马亚区体积是否存在性别差异。方法采用中国多中心主观认知下降纵向研究(SILCODE)中认知正常老年人238人,其中男82人,女156人。基于结构磁共振成像(sMRI)提取海马及其亚区体积,并通过建立多元线性回归模型,校正痴呆家族史、年龄、教育程度及海马总体积对海马亚区体积的性别差异进行分析。结果校正痴呆家族史、年龄、教育程度及海马总体积,女性组左前下托、左旁下托、左侧齿状回颗粒细胞层(GC-ML-DG)、左侧海马-杏仁核过渡区(HATA)、右侧旁下托体积明显低于男性组(P<0.05)。进行多重比较校正,女性组左旁下托体积明显低于男性组(P<0.05/12)。结论认知正常老年人海马亚区体积存在性别差异。

Objective To investigate whether there are sex differences in hippocampal subfield volumes in cognitively normal elderly.Methods A cross-sectional study was carried out,with 238 cognitively normal elderly consecutive participants(82 men and 156 women)of the Sino Longitudinal Study on Cognitive Decline(SILCODE)study.The volumes of hippocampus and its subregion were extracted based on structural magnetic resonance imaging(sMRI),and the sex differences in hippocampal subfield volume were analyzed by establishing a multiple linear regression model,adjusting for family history of dementia,age,education level and total volume of hippocampus.Results After adjusting for family history of dementia,age,education level and total volume of hippocampus,the volume of left anterior inferior bracket,left collateral inferior bracket,left granular cell layer of dentate gyrus(GC-ML-DG),left hippocampal-amygdala transition area(HATA)and right collateral inferior bracket in female group were significantly lower than those in male group(P<0.05).After multiple comparison correction,the left collateral inferior bracket volume in female group was significantly lower than that in male group(P<0.05/12).Conclusions There are gender differences in hippocampal subfield volume in the cognitively normal elderly.