低频重复经颅磁刺激影响青少年抑郁症自杀意念

Effects of Low-frequency Repetitive Transcranial Magnetic Stimulation on Suicidal Ideation in Adolescents with Depression

目的:通过实验探讨低频经颅磁刺激作用于右侧背外额叶治疗对有自杀意念的青少年抑郁症群体的作用。方法:选取32名有自杀意念的青少年抑郁症患者(平均年龄17.00岁,SD=2.286,range=13-21)随机分为研究组和对照组,两组均给予常规药物治疗,同时分别给予为期两周的真假经颅磁刺激治疗,在治疗前后分别以汉密尔顿抑郁量表(HAMD24)、抑郁自评量表(SDS)、贝克自杀意念量表(BSI-CV)对治疗效果进行评定。结果:两组患者治疗前量表评分无显著差异(P>0.05),治疗后两组评分均有不同程度降低,研究组与对照组相比效果更显著(P<0.05)。结论:低频重复经颅磁刺激能够在两周的治疗中改善青少年抑郁症患者的症状,改善患者的认知障碍和绝望感等,降低自杀意念强度。

Objective:This study aimed to explore the efficacy of a two weeks’course of repetitive transcranial magnetic stimulation(rTMS)treatment on adolescent patients of depression disorder,to relive their depressive symptoms,and reduce the suicidal ideation within the patients.Methods:Within randomized single-blinded trails,adolescent patients of depression disorder with a mean age of 17.00 years(n=32,SD=2.286,range=13-21)were assessed using 24-iterm Hamilton Depression Scale(HAMD24),Self-rating depression scale(SDS)and Beck scale for suicide ideation(BSI-CV)before and after treatment.The patients were randomly divided into two group:true-stimulation group,sham-stimulation group.The statistic of t-tests were used to compare pre/post scores of factors on HDRS,SDS,BSI-CV.Results:There were no significant differences in the scale scores between the two groups before treatment(all P>0.05).After treatment,the scores of both groups decreased to different degrees,and the effect was more significant in the study group than in the control group(P<0.05).Conclusion:rTMS treatment can reduce symptoms in adolescents with depression over the course of two weeks,and can also reduce the intensity of suicidal ideation.